Pulmonary dysfunction as a major cause of inoperability among patients with non-small-cell lung cancer

Clinical Lung Cancer
Sevin BaserR C Morice

Abstract

We wanted to assess the prevalence of pulmonary dysfunction as the underlying reason for inoperability among patients with non-small-cell lung cancer (NSCLC) who were considered for surgical treatment at the time of diagnosis. This is a retrospective analysis of all patients with NSCLC referred to our pulmonary function laboratory for preoperative evaluation between January 2001 and November 2001. Pulmonary function testing consisted of measurement of spirometric indices (forced expiratory volume in 1 second [FEV1]), lung volumes and diffusing capacity for carbon monoxide, Xenon-133 quantitative ventilation and perfusion studies, and exercise testing when indicated. Patient demographics and clinical characteristics at the time of the evaluation were reviewed. The group comprised 206 consecutive potential surgical candidates (mean age, 64.7 years +/- 10.1 years) with NSCLC. Nearly half (45.6%) of the patients had early-stage (I/II) disease, and the remainder had late-stage disease at the time of pulmonary evaluation. The average predicted FEV1 among all patients was 70.3% +/- 19.6% (range, 25%-123%). One hundred eight patients (52.4%) were deemed surgically inoperable after the preoperative assessment. Severe pulmonary function ...Continue Reading

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References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·M K FergusonR Mick
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
May 16, 1998·The European Respiratory Journal·C T Bolliger, A P Perruchoud
Feb 16, 2000·Chest·G T Ferguson
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jan 16, 2003·Chest·Michael A BecklesUNKNOWN American College of Chest Physicians
Jun 11, 2003·Chest·Debapriya Datta, Bimalin Lahiri
Jun 14, 2003·Current Opinion in Pulmonary Medicine·Chris Thomas Bolliger
Jun 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Piergiorgio SolliUgo Pastorino
Feb 24, 2005·Current Opinion in Oncology·Fiona H BlackhallNicholas Thatcher
Apr 2, 2005·The European Respiratory Journal·T WinC M Laroche
Jun 1, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F De MarinisL De Petris
Jun 2, 2005·Current Opinion in Pulmonary Medicine·Chris T BolligerRosamund Kendal

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Citations

Apr 14, 2010·Expert Review of Respiratory Medicine·Peter J Mazzone
Mar 16, 2016·BMC Surgery·Shinjiro MizuguchiNoritoshi Nishiyama
Jun 12, 2013·Revue des maladies respiratoires·P BaganH De Crémoux
Sep 17, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Se Joong KimChoon-Taek Lee
Dec 4, 2016·Asian Cardiovascular & Thoracic Annals·Asra HashmiShirish M Gadgeel
Jun 10, 2010·Current Opinion in Pulmonary Medicine·Vickie R Shannon
Jul 31, 2018·Interactive Cardiovascular and Thoracic Surgery·Alix MarhicPatrick Bagan
Jan 18, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Ciara HanleyPeter Slinger

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