Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation

Anesthesia and Analgesia
M A ChaneyS Slogoff

Abstract

Numerous clinical studies suggest that methylprednisolone may facilitate early tracheal extubation after cardiac surgery, yet no investigation has rigorously examined the use of the drug in this setting. In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting (CABG) and early tracheal extubation. Sixty patients undergoing elective CABG and early tracheal extubation were randomized into two groups. Group MP patients received i.v. methylprednisolone (30 mg/kg during sternotomy and 30 mg/kg during initiation of cardiopulmonary bypass) and Group NS patients received i.v. placebo at the same two times. Perioperative management was standardized. Alveolar-arterial (A-a) oxygen gradient, lung compliance, shunt, and dead space were determined four times perioperatively. Postoperative tracheal extubation was accomplished at the earliest appropriate time. Both groups exhibited significant postoperative increases in A-a oxygen gradient and shunt (P < 0.000001 for each group) and significant postoperative decreases in dynamic lung compliance (P < 0.000001 for each group). Patients in Group MP exhibited significantl...Continue Reading

References

Mar 1, 1978·Anaesthesia·T V GnanaduraiE Welman
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·N J JansenC R Wildevuur
Jan 1, 1987·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E FosseA O Aasen
Aug 1, 1966·The Journal of Surgical Research·M L MosesT F Nealon
Jan 1, 1980·Anaesthesia·P L HaslamM A Branthwaite
Sep 1, 1995·The Annals of Thoracic Surgery·R M EngelmanD K Das
Mar 1, 1994·Anesthesiology·T HachenbergG Hedenstierna
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·G E HillR A Robbins
Dec 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·G E HillR A Robbins
Feb 1, 1996·The Annals of Thoracic Surgery·S WanJ L LeClerc
Feb 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·R P DiegoG E Hill
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D Royston

❮ Previous
Next ❯

Citations

Jul 6, 2000·The Annals of Thoracic Surgery·J P YaredT E Rosenberger
Jul 5, 2003·The Annals of Thoracic Surgery·Pierpaolo GiomarelliBonizella Biagioli
Jun 28, 2000·Journal of Clinical Anesthesia·P Tassani
Nov 20, 2002·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet
Jan 13, 2010·Journal of Cardiothoracic Surgery·Efstratios E ApostolakisGeorgios S Papadopoulos
Aug 9, 2011·Critical Care : the Official Journal of the Critical Care Forum·Frederique PaulusMarcus J Schultz
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Richard I Hall
Nov 4, 2009·The American Journal of the Medical Sciences·Konstantinos ToutouzasChristodoulos Stefanadis
Jan 21, 2014·Journal of Clinical Anesthesia·Joanne Guay, E Andrew Ochroch
Sep 24, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Glenn S MurphyJohn G T Augoustides
Jan 29, 2013·The Annals of Thoracic Surgery·R Scott StephensGlenn J R Whitman
Sep 4, 2012·Heart, Lung & Circulation·Vladimir V LomivorotovAlexander M Karaskov
Apr 12, 2002·Chest·Calvin S H NgAhmed A Arifi
Jun 12, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Giangiuseppe CappabiancaDomenico Paparella
Feb 18, 2010·Current Problems in Surgery·Avihu Z GazitA Thomas Pezzella
Dec 5, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Oliver J WarrenThanos Athanasiou
Jul 30, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Praveen Kumar NeemaMohammed M Minhaj
Apr 3, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·William L BakerCraig I Coleman
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Shahzad G Raja, Gilles D Dreyfus
Dec 17, 1998·Journal of Cardiothoracic and Vascular Anesthesia·M A ChaneyM Bakhos
Dec 15, 2005·Heart, Lung & Circulation·Aitizaz SyedArto Nemlander
Mar 29, 2006·The Journal of Surgical Research·R P WhitlockK H Teoh
Apr 10, 2014·Hospital Pharmacy·Judith L KristellerTravis Reinaker
Nov 21, 2007·Journal of the American College of Cardiology·Tim T IssacNasser M Lakkis
Apr 28, 2007·International Journal of Surgery·J R S Day, K M Taylor
Apr 29, 2014·American Heart Journal·Richard WhitlockSalim Yusuf
Oct 29, 2000·Journal of Cardiothoracic and Vascular Anesthesia·M A ChaneyM Bakhos
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·M A ChaneyM Bakhos
Sep 1, 1999·Journal of Cardiothoracic and Vascular Anesthesia·S L LarsonB K Foy
Dec 17, 2010·World Journal of Cardiology·Mehmet Ozaydin
May 13, 2011·The Cochrane Database of Systematic Reviews·Jan M DielemanOlaf M Dekkers
Nov 30, 1999·Anesthesia and Analgesia·M A Chaney, M P Nikolov
Oct 4, 2006·Current Opinion in Anaesthesiology·C Weissman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.