Abstract
Cardiac implantable electronic devices (CIEDs) are commonly associated with transvenous lead-related thrombi that can cause pulmonary embolism (PE). We retrospectively evaluated all patients with transvenous CIED leads implanted at Mayo Clinic Rochester between 1 January 2000, and 25 October 2010. Pulmonary embolism outcomes during follow-up were screened using diagnosis codes and confirmed with imaging study reports. Of 5646 CIED patients (age 67.3 ± 16.3 years, 64% men, mean follow-up 4.69 years) 88 developed PE (1.6%), incidence 3.32 [95% confidence interval (CI) 2.68-4.07] per 1000 person-years [men: 3.04 (95% CI 2.29-3.96) per 1000 person-years; women: 3.81 (95% CI 2.72-5.20) per 1000 person-years]. Other than transvenous CIED lead(s), 84% had another established risk factor for PE such as deep vein thrombosis (28%), recent surgery (27%), malignancy (25%), or prior history of venous thromboembolism (15%). At the time of PE, 22% had been hospitalized for ≥ 48 h, and 59% had been hospitalized in the preceding 30 days. Pulmonary embolism occurred in 22% despite being on systemic anticoagulation therapy. Out of 88 patients with PE, 45 subsequently died, mortality rate 93 (95% CI 67-123) per 1000 person-years (hazard ratio 2.0,...Continue Reading
References
Mar 1, 1986·Pacing and Clinical Electrophysiology : PACE·W Seeger, K Scherer
Aug 1, 1987·Journal of the American College of Cardiology·I SingerS Fisher
Aug 1, 1987·Angiology·A PorathI Ovsyshcher
Jul 1, 1996·Pacing and Clinical Electrophysiology : PACE·H G Mond, K B Stokes
Apr 1, 1998·Archives of Internal Medicine·M D SilversteinL J Melton
May 4, 2000·Pacing and Clinical Electrophysiology : PACE·C C de CockC A Visser
Apr 5, 2001·The New England Journal of Medicine·C OzcanW K Shen
Apr 20, 2001·Pacing and Clinical Electrophysiology : PACE·K WierzbowskaJ D Kasprzak
Oct 17, 2002·Pacing and Clinical Electrophysiology : PACE·Sergio Sidney do Carmo Da CostaMartino Martinelli Filho
Dec 31, 2002·The American Journal of Cardiology·Benjamin J W ChowAnthony S L Tang
Jul 25, 2003·Pacing and Clinical Electrophysiology : PACE·Frank BrackeBerry Van Gelder
Jun 24, 2004·Echocardiography·Apostolos KaravidasApostolos Zacharoulis
Oct 7, 2004·The American Journal of Medicine·Hsin-Bang LeuTsui-Lieh Hsu
Oct 30, 2004·The Annals of Thoracic Surgery·David B ColemanHenry M Spotnitz
Dec 3, 2004·Journal of Cardiovascular Electrophysiology·Cornelis J van RoodenMenno V Huisman
Nov 15, 2006·Pacing and Clinical Electrophysiology : PACE·Petri J KorkeilaKarl Eino Juhani Airaksinen
Mar 21, 2007·Journal of Thrombosis and Haemostasis : JTH·I A NaessJ Hammerstrøm
May 16, 2007·Circulation·William H Maisel
Apr 5, 2008·Angiology·Marijan KirinIvan Kirin
Aug 18, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Miroslav NovakJolana Lipoldova
Mar 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Petri KorkeilaJuhani Airaksinen
Feb 1, 2011·Vascular and Endovascular Surgery·Kwame S AmankwahVivian Gahtan
Jul 26, 2011·Revista Española De Cardiología·João Silva MarquesJoão de Sousa
Jul 27, 2011·Circulation·Gregory E SuppleFrancis E Marchlinski
Aug 16, 2013·Circulation·Christopher V DeSimoneSamuel J Asirvatham
Sep 3, 2013·BMJ Case Reports·Antonio D'AloiaAntonio Curnis
Apr 29, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Vaibhav R VaidyaPaul A Friedman
Citations
Feb 24, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Charles J LenzSamuel J Asirvatham
Dec 10, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alan SugrueSamuel J Asirvatham
Jun 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Susanne Bendesgaard PedersenJens Cosedis Nielsen
Dec 13, 2016·Pacing and Clinical Electrophysiology : PACE·Shiva P PonamgiSamuel J Asirvatham
Jan 8, 2019·Journal of Pharmacy Practice·Thomas M Ellington
Jan 30, 2016·Nature Reviews. Cardiology·Oussama Wazni, Bruce L Wilkoff
Apr 12, 2020·Pacing and Clinical Electrophysiology : PACE·Caio Marcos de Moraes AlbertiniRoberto Costa
Apr 26, 2019·European Heart Journal. Case Reports·Margos N PanagiotisKranidis I Athanasios
May 22, 2020·BMJ Case Reports·Sofia AlegriaMaria José Loureiro
Nov 24, 2018·JACC. Clinical Electrophysiology·Amit NoheriaSamuel J Asirvatham
Jun 22, 2019·JACC. Clinical Electrophysiology·Gordon HoUlrika Birgersdotter-Green
Jun 3, 2021·Journal of Cardiovascular Pharmacology·Murti PatelCory R Trankle
Jul 3, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Abhishek BoseSanjeev B Goyal