Pulmonary emphysema decreases hamster skeletal muscle oxidative enzyme capacity

Journal of Applied Physiology
J P Mattson, D C Poole

Abstract

Skeletal muscle oxidative enzyme capacity is impaired in patients suffering from emphysema and chronic obstructive pulmonary disease. This effect may result as a consequence of the physiological derangements because of the emphysema condition or, alternatively, as a consequence of the reduced physical activity level in these patients. To explore this issue, citrate synthase (CS) activity was measured in selected hindlimb muscles and the diaphragm of Syrian Golden hamsters 6 mo after intratracheal instillation of either saline (Con, n = 7) or elastase [emphysema (Emp); 25 units/100 g body weight, n = 8]. Activity level was monitored, and no difference between groups was found. Excised lung volume increased with emphysema (Con, 1.5 +/- 0.3 g; Emp, 3.0 +/- 0.3 g, P < 0.002). Emphysema significantly reduced CS activity in the gastrocnemius (Con, 45.1 +/- 2.0; Emp, 39.2 +/- 0.8 micromol . min-1 . g wet wt-1, P < 0.05) and vastus lateralis (Con, 48.5 +/- 1.5; Emp, 44.9 +/- 0.8 micromol . min-1 . g wet wt-1, P < 0.05) but not in the plantaris (Con, 47.4 +/- 3.9; Emp, 48.0 +/- 2.1 micromol . min-1 . g wet wt-1, P < 0.05) muscle. In contrast, CS activity increased in the costal (Con, 61.1 +/- 1.8; Emp, 65.1 +/- 1.5 micromol . min-1 . g ...Continue Reading

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Citations

Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·R DebigaréF Maltais
Jul 10, 2003·Journal of Applied Physiology·Jill E SheaJohn P Mattson
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Russell S RichardsonPeter D Wagner
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Harry R GoskerAnnemie M W J Schols
Jan 30, 2009·Respiratory Research·Lars LüthjeStefan Andreas
Mar 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Gwenael LayecRussell S Richardson
Mar 31, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hans DegensStephen E Alway
Mar 10, 2005·Experimental Physiology·John P Mattson, James C Martin
Aug 18, 2009·Clinical Science·William D-C ManMichael I Polkey
Dec 25, 2012·Journal of Applied Physiology·Sanford LevineSunil Singhal
May 8, 2000·Journal of Applied Physiology·P PalangeS Carlone
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Anne K SwisherRachel Yeater
Apr 11, 2009·Journal of Applied Physiology·Thomas L Clanton, Sanford Levine
Jan 24, 2018·Journal of Applied Physiology·Jayson R GiffordRussell S Richardson
Dec 20, 2007·Medicine and Science in Sports and Exercise·Bruno T RoseguiniJorge P Ribeiro
Jul 21, 2012·Journal of Applied Physiology·Bram van den BorstHarry R Gosker
Feb 24, 2001·Clinics in Chest Medicine·F MaltaisR Casaburi
Dec 27, 2005·Respiratory Physiology & Neurobiology·Leonardo F FerreiraDavid C Poole

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