Jun 10, 2008

Pulmonary eosinophilia correlates with allergen deposition to the lower respiratory tract in a mouse model of asthma

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
S SiddiquiL K Silbart


Eosinophilic infiltration into the airways is frequently associated with allergic asthma; however, the role of antigen deposition in mediating this phenomenon has not been studied in detail. Using a murine model of ovalbumin (OVA) allergy, we examined how differential deposition of OVA during antigen challenge affects pulmonary eosinophilia, immune response and airway hyper-reactivity (AHR). Differential allergen deposition to the upper respiratory tract (URT) alone or combined upper and lower respiratory tract (ULRT) was accomplished by administering OVA intranasally to either anaesthetized or unanaesthetized mice, respectively. BALB/c mice (6-7 weeks old) were sensitized with OVA-alum via the intraperitoneal route, and then challenged intranasally using OVA, with or without anaesthesia. AHR, enumeration of inflammatory cells and quantitative measurement of inflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF), lung histopathology and immune responses were subsequently assessed. In sensitized animals challenged via the ULRT route, a profound eosinophilia and goblet cell hyperplasia was observed in lung tissue. Conversely, sensitized mice receiving an identical challenge dose via the URT route alone exhib...Continue Reading

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Mentioned in this Paper

Immune Response
Carcinoid Tumor
Alum Compounds
Mice, Inbred BALB C
Entire Upper Respiratory Tract (Body Structure)
Bronchial Provocation Tests

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