PMID: 9657557Jul 10, 1998Paper

Pulmonary fibrosis: cytokines in the balance

The European Respiratory Journal
R K Coker, G J Laurent

Abstract

Pulmonary fibrosis can complicate diverse pulmonary and systemic pathologies. In many cases the underlying cause remains unidentified. Mortality from the disease is increasing steadily in the UK and USA. The clinical features are well-described, but patients frequently present at an advanced stage, and current treatments have not improved the poor prognosis. There is a compelling need to identify the fibrotic process earlier and to develop new therapeutic agents. Increased collagen deposition is central to the pathology and interest over the last decade has focused on the role of cytokines in this process. These polypeptide mediators are believed to be released from both circulating inflammatory and resident lung cells in response to endothelial and epithelial injury. Key cytokines currently implicated in the fibrotic process are transforming growth factor-beta, tumour necrosis factor-alpha and endothelin-1. This article outlines the evidence implicating these mediators in the pathogenesis of pulmonary fibrosis and also considers the possible role of cytokines with antifibrotic effects, such as interferon-gamma. The "balance" of positively and negatively regulating cytokines is discussed, and the potential for interaction with ...Continue Reading

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·C FonsecaC M Black
Sep 4, 2004·Indian Journal of Pediatrics·Anil VasudevanS K Kabra
Oct 12, 2004·Archives of Pharmacal Research·Seon Il JangKyu-Yun Chai
Aug 13, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mingzhe YuJun Li
Aug 21, 2013·Environmental Toxicology and Pharmacology·Ramesh VermaBalakrishnan Suresh
Mar 10, 2001·The American Journal of Pathology·G KrishnaG D Rosen
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·S T HolgateJ L Lordan
Dec 10, 1999·Lancet·J J Egan
Apr 8, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C E FisherK Donaldson
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·J SpondM Minnicozzi
Dec 28, 1999·Microbes and Infection·M H Branton, J B Kopp
May 22, 2003·Paediatric Respiratory Reviews·Janis ShuteAndrew Bush
Apr 27, 2010·Acta Pharmacologica Sinica·Li-jun ChenGuang-mei Yan
Dec 19, 2000·Histopathology·J Britton, R Hubbard
Dec 21, 2000·Immunology·J Zhang-HooverJ Stein-Streilein
Jan 9, 2004·The New England Journal of Medicine·Ganesh RaghuUNKNOWN Idiopathic Pulmonary Fibrosis Study Group
Jan 28, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ulrike Carolin Müller-QuernheimGernot Zissel
Aug 26, 1999·Current Opinion in Pulmonary Medicine·S K JindalA N Aggarwal
Mar 3, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Monique A MaloufUNKNOWN Everolimus in IPF Study Investigators
Apr 30, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·A E CurrieS Kotecha
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Bruno Battistini
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R P MarshallG J Laurent
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Matthew ConronBrian M J Foxwell
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Patrizia PignattiGianna Moscato
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·F TakahashiY Fukuchi
Apr 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Yuben P MoodleyDarryl A Knight
Jul 5, 2003·American Journal of Respiratory Cell and Molecular Biology·Moumita GhoshChristina C Leslie
Feb 21, 2004·American Journal of Respiratory Cell and Molecular Biology·Virginie BarbarinFrançois Huaux
Jan 21, 2006·American Journal of Respiratory Cell and Molecular Biology·Mohammed ArrasFrançois Huaux
Jul 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Tao TaoFeige Kaplan
Nov 17, 2009·Respiratory Research·Jian QiaoLihong Zhao
Feb 15, 2013·Respiratory Research·Anna-Karin Larsson-CallerfeltGunilla Westergren-Thorsson
May 2, 2013·BMC Complementary and Alternative Medicine·Juyeong LeeHo-Young Choi
Jul 8, 2011·Journal of Inflammation·Sungwon LeeKyungjae Kim
Apr 12, 2008·Proceedings of the American Thoracic Society·Geoffrey J LaurentRachel Chambers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Marco E AllaixMarco G Patti
© 2022 Meta ULC. All rights reserved