PMID: 6111265Jan 1, 1980Paper

Pulmonary fibrous ground substance. Macromolecules of the intercellular matrix

Annales de l'anesthésiologie française
L Robert

Abstract

Four families of macromolecules make up the pulmonary fibrous connective tissue which one finds in all connective tissue: collagen elastin, the proteoglycans and the structural glycoproteins. The regulation of the synthesis of these macromolecules and their arrangement and interaction within the intracellular space are conditions necessary for the development and maintenance of a normal pulmonary fibrous connective tissue. The quantitative relationship of these macromolecules changes with age; it is also profoundly modified in chronic obstructive lung disease. An understanding of the pathogenesis of the modifications, requires the study of the regulatory mechanisms involved in the synthesis and degradation of the macromolecules of the pulmonary connective tissue. In recent years we have made some progress in the domain of the regulation of the synthesis and degradation of collagen, but we still know very little about elastin. Over the past few years our laboratory has isolated several cellular elastases which probably intervene in these processes. Elastoplastic proteases have been isolated from platelets, leucocytes, macrophages, fibroblasts and smooth muscle cells. Human serum and purified lipoproteins also possess an elastoly...Continue Reading

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.