Pulmonary Flow as an Improved Method for Determining Cardiac Output in Mice after Myocardial Infarction

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Mathew J PlattJeremy A Simpson

Abstract

Echocardiography is a valuable noninvasive technique to estimate cardiac output (CO) from the left ventricle (LV) not only in clinical practice but also in small-animal experiments. CO is used to grade cardiac function and is especially important when investigating cardiac injury (e.g., myocardial infarction [MI]). Critically, MI deforms the LV, invalidating the assumptions fundamental to calculating of cardiac volumes directly from the LV. Thus, the purpose of this study was to determine if Doppler-derived blood flow through the pulmonary trunk (pulmonary flow [PF]) was an improved method over conventional LV-dependent echocardiography to accurately determine CO after MI. Variations in CO were induced either by transverse aortic constriction or MI. Echocardiography was performed in healthy (n = 27), transverse aortic constriction (n = 25), and MI (n = 41) mice. CO calculated from PF (pulsed-wave Doppler) was internally compared with CO calculated from left ventricular images using M-mode (Teichholz formula) and the single-plane ellipsoid two-dimensional (2D) formula and externally compared with the gold standard, flow probe CO. In healthy mice, all three echocardiographic methods (M-mode, 2D, and PF) correlated well with flow ...Continue Reading

Citations

Aug 14, 2018·Canadian Journal of Physiology and Pharmacology·Sara A RuggieroJeremy A Simpson
Mar 8, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cynthia M F MonacoGraham P Holloway
Jul 3, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Leslie M OgilvieJeremy A Simpson
Oct 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyZamaneh Kassiri

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