Pulmonary formation of prostacyclin in man

Prostaglandins
A EdlundA Wennmalm

Abstract

The pulmonary formation of prostacyclin (PGI2), as reflected by the difference in concentration of pulmonary and systemic arterial radioimmunoassayed 6-keto-PGF1 alpha, was determined in six healthy waking subjects. The systemic arterial 6-keto-PGF1 alpha levels were low (less than or equal to 50 pg/ml), and no evidence of pulmonary formation and release of the compound was noted. In other experiments systemic arterial 6-keto-PGF1 alpha levels were determined in patients prior to and during artificial ventilation, as well as during and after occlusion of the pulmonary circulation (extra-corporeal circulation, ECC). The arterial 6-keto-PGF1 alpha concentration prior to artificial ventilation was 17 +/- 4 pg/ml, i.e. within the range observed in the healthy subjects. During artificial ventilation the arterial levels of 6-keto-PGF1 alpha increased to 191 +/- 21 pg/ml, suggesting that pulmonary formation of PGI2 was stimulated. In the patients subjected to ECC with occluded pulmonary circulation the arterial content of 6-keto-PGF1 alpha was stabilised at an elevated level (120-170 pg/ml). Following re-establishment of the pulmonary circulation the arterial concentrations of 6-keto-PGF1 alpha increased markedly, to 284 +/- 50 pg/ml....Continue Reading

References

Dec 1, 1979·Lancet·C N HensbyH Dargie
Jun 29, 1978·Nature·S MoncadaJ R Vane
Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
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Mar 1, 1981·Prostaglandins·C PatronoS Chierchia

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Citations

Apr 1, 1982·Prostaglandins·I A BlairC T Dollery
Jul 1, 1982·Prostaglandins·A EdlundA Wennmalm
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·G DavìA Strano
Sep 1, 1987·Prostaglandins, Leukotrienes, and Medicine·S KaukinenH Vapaatalo
May 18, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M KluckowJ Rowe
Nov 1, 1995·Canadian Journal of Physiology and Pharmacology·L CharetteT R Jones
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniC Patrono
Aug 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S KaukinenH Vapaatalo
Aug 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F A PeetersA G Herman

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