Jun 26, 2014

Pulmonary function after hemorrhagic shock and resuscitation in a porcine model

Acta Anaesthesiologica Scandinavica
T K NielsenAsger Granfeldt

Abstract

Hemorrhagic shock may trigger an inflammatory response and acute lung injury. The combination adenosine, lidocaine (AL) plus Mg(2+) (ALM) has organ-protective and anti-inflammatory properties with potential benefits in resuscitation.The aims of this study were to investigate: (1) pulmonary function and inflammation after hemorrhagic shock; (2) the effects of ALM/AL on pulmonary function and inflammation. Pigs (38 kg) were randomized to: sham + saline (n = 5); sham + ALM/AL (n = 5); hemorrhage control (n = 11); and hemorrhage + ALM/AL (n = 9). Hemorrhage animals bled to a mean arterial pressure (MAP) of 35 mmHg for 90 min, received resuscitation with Ringer's acetate and 20 ml of 7.5% NaCl with ALM to a minimum MAP of 50 mmHg, after 30 min shed blood and 0.9% NaCl with AL were infused. Hemorrhage controls did not receive ALM/AL. Primary endpoints were pulmonary wet/dry ratio, PaO2 /FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen), cytokine and protein measurements in bronchoalveolar lavage fluid (BALF) and lung tissue, neutrophil invasion and blood flow in lung tissue. In the hemorrhage groups, wet/dry ratio increased significantly compared with the sham groups. PaO2 /FiO2 ratio decreased durin...Continue Reading

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Citations

Mentioned in this Paper

Arterial Pulse Pressure
Salicylhydroxamic acid
Systemic Inflammatory Response Syndrome
Bronchioloalveolar Adenocarcinoma
Adenosine
Lung
Anti-Inflammatory Agents
Alveolar
Oxygen Measurement, Partial Pressure, Arterial
Oxidative Stress

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