Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing

Allergy
Annamari KoistinenTuomas Jartti

Abstract

Wheezing illnesses among young children are common and are a risk factor for asthma. However, determinants of childhood bronchial reactivity, a key feature of asthma, are largely unknown. The aim of this study was to determine how patient characteristics during the first severe virus-induced wheezing episode are associated with pulmonary function at preschool age. Study consisted of 76 children presenting with their first wheezing episode at the ages of 3 to 23 months. At study entry, viral etiology, rhinovirus genome load, atopic and clinical characteristics, and standardized questionnaire were analyzed. At 4-year follow-up visit, impulse oscillometry with exercise challenge was performed. At study entry, the mean age of the children was 12 months (SD 6.0), 57 (75%) were rhinovirus positive, and 22 (30%) were sensitized. At follow-up visit four years later, the mean age of the children was 60 months (SD 7.9) and 37 (49%) were using asthma medication regularly (discontinued before testing in 25 [68%] children). Bronchial reactivity (≥35% change in mean crude values of resistance) after exercise challenge or bronchodilation was present in nine (12%) children. Children with atopic sensitization at the time of the first wheezing e...Continue Reading

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Citations

Jan 29, 2020·Seminars in Immunopathology·Tuomas JarttiWojciech Feleszko
Mar 21, 2020·Allergy·Xiang DongYa-Dong Gao
May 30, 2020·Allergy·Tuomas JarttiUNKNOWN EAACI Task Force on Clinical Practice Recommendations on Preschool Wheeze
Dec 3, 2020·Respiratory Research·Meghana RastogiSunit K Singh
Apr 26, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Marianna KarachaliouManolis Kogevinas

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT00731575

Software Mentioned

SPSS

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