PMID: 2105409Jan 1, 1990Paper

Pulmonary function and bronchial reactivity in asthmatics during low-level formaldehyde exposure

Lung
H HarvingR Dahl

Abstract

This study evaluated whether formaldehyde, at concentrations similar to those found in the indoor environment, could produce adverse effects on the lower airway of 15 asthmatic persons with documented bronchial hyperresponsiveness who were exposed for 90 min in a climate chamber to clean air containing formaldehyde vapor at levels of 0.85 mg/m3, 0.12 mg/m3, and 0.008 mg/m3. No significant changes in forced expiratory volume in 1 sec (FEV1), airway resistance (Raw), specific airway resistance (SRaw), and flow-volume curves could be detected during formaldehyde exposure. Furthermore, histamine challenge tests performed immediately after formaldehyde exposure showed no evidence of changes in bronchial reactivity. No late reactions were registered during the first 14-16 hr after exposure. The results suggest that residential levels of formaldehyde are of minor importance in the emergence of pulmonary symptoms. Discrepancies between the present study and previous data may be due to differences in environmental conditions.

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Citations

Feb 18, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·R G Liteplo, M E Meek
Jun 12, 2013·Revue des maladies respiratoires·N MithaG Ibanez
Jun 19, 2010·Environment International·Peder Wolkoff, Gunnar D Nielsen
Sep 13, 2008·Regulatory Toxicology and Pharmacology : RTP·Josje H E ArtsRuud A Woutersen
Aug 4, 2015·Environmental Science and Pollution Research International·Naruwan SaowakonRachain Kosanlavit
Oct 19, 2007·Regulatory Toxicology and Pharmacology : RTP·Isabelle LangGerhard Triebig
Feb 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M B Schenker, J A Jacobs
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Sep 28, 2005·Regulatory Toxicology and Pharmacology : RTP·Masato Naya, Junko Nakanishi
Feb 16, 2002·Regulatory Toxicology and Pharmacology : RTP·Joel Bender
May 28, 2015·Journal of Pharmacy & Bioallied Sciences·P UthiraveluV Vaithiyanandane
Nov 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Pierre Edouard KastnerFrançoise Pons
Jul 21, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Robert Dales, Mark Raizenne
Feb 25, 2021·Journal of the Air & Waste Management Association·Patrick HenaultGérard Provot

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