Abstract
The present study was undertaken to test the hypothesis that chronic, low-level paraquat exposure causes restrictive lung function with gas transfer impairment. Three hundred thirty-eight Costa Rican farm workers from banana, coffee, and palm oil farms completed a questionnaire, spirometry, and a test of single-breath carbon monoxide diffusing capacity. Subjects 40 years of age or older, without other medical risk factors, completed maximal cardiopulmonary exercise tests. Most (66.6%) were paraquat handlers; 24.8% of handlers and 27.3% of nonhandlers reported current cigarette smoking. In linear regression models, cumulative paraquat exposure was not an independent predictor of VA, carbon monoxide diffusing capacity, peak oxygen uptake, FVC, or oxygen pulse peak. However, the ventilatory equivalent for CO(2), although within normal range, was significantly higher with increased cumulative paraquat exposure. Oxygen desaturation greater than 5% from rest to peak exercise had an odds ratio of 1.7 (95% confidence interval = 0.9-3.0) with the cumulative paraquat exposure index in models adjusted for age, weight, and smoking status. The association of paraquat exposure with ventilatory equivalent and oxygen desaturation suggests that...Continue Reading
References
Aug 1, 1979·British Journal of Industrial Medicine·J K Howard
Apr 27, 1978·The New England Journal of Medicine·G R EplerC B Carrington
Jan 1, 1976·Medicine, Science, and the Law·R D Teare
Oct 1, 1991·AJR. American Journal of Roentgenology·J G ImI O Kim
Nov 1, 1991·The American Review of Respiratory Disease
Jun 1, 1991·The American Review of Respiratory Disease·P L EnrightA S Buist
Jul 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C BismuthC Keyes
Jun 1, 1989·International Journal of Epidemiology·J Hettiarachchi, G C Kodithuwakku
Jan 1, 1987·Human Toxicology·L J Onyon, G N Volans
Oct 1, 1987·Clinical Physiology·I Nordenfelt, G Svensson
Aug 8, 1974·The New England Journal of Medicine·G M CoplandH S Shulman
Feb 1, 1973·Chest·E A Gaensler, A A Smith
Oct 1, 1971·British Journal of Industrial Medicine·C E Hearn, W Keir
Jan 1, 1971·The American Review of Respiratory Disease·J F MorrisL C Johnson
Feb 1, 1982·British Journal of Industrial Medicine·G Chester, B H Woollen
May 1, 1981·British Journal of Industrial Medicine·J K HowardP A Whitehead
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Aug 1, 1993·Scandinavian Journal of Work, Environment & Health·C WesselingC G Elinder
Jan 1, 1994·Physical Therapy·L J MengelkochJ Lawler
Mar 1, 1993·British Journal of Industrial Medicine·N SenanayakeV Basanayake
Mar 1, 1993·Archives of Environmental Health·R TinocoD Halperin
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine
Nov 5, 1997·American Journal of Industrial Medicine·C WesselingL Johansson
Feb 26, 1998·Scandinavian Journal of Work, Environment & Health·N Castro-GutiérrezC Hogstedt
May 21, 1999·International Journal of Legal Medicine·S K LeeI Ijiri
Sep 4, 1999·Occupational and Environmental Medicine·M A DalvieD C Christiani
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·R O CrapoP J Sterk
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Jane A HoppinDale P Sandler
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Citations
Dec 10, 2008·Journal of Agromedicine·Eun-Kee ParkMarc B Schenker
Dec 22, 2006·Occupational and Environmental Medicine·Leda ChatziChristos Lionis
Aug 27, 2005·American Journal of Respiratory and Critical Care Medicine·Mohamed Aqiel DalvieJonathan E Myers
Aug 27, 2005·American Journal of Respiratory and Critical Care Medicine·J Manuel Tunon-de-LaraRoger Marthan
Mar 9, 2005·American Journal of Respiratory and Critical Care Medicine·Benoit NemeryEdward Abraham
Jun 23, 2009·The European Respiratory Journal·J A HoppinD P Sandler
Sep 28, 2012·Journal of Occupational Medicine and Toxicology·Xaver BaurHenning Vellguth
Nov 30, 2013·International Journal of Environmental Research and Public Health·Ming YeAmbikaipakan Senthilselvan
Nov 14, 2013·Occupational and Environmental Medicine·Jane A Hoppin
Oct 22, 2013·Occupational and Environmental Medicine·K de JongUNKNOWN LifeLines Cohort study
Apr 18, 2009·American Journal of Epidemiology·Karin B FietenBerna van Wendel de Joode
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B RiahiG Karimi
Jun 10, 2016·International Journal of Experimental Pathology·Rômulo D NovaesAntônio J Natali
Jun 20, 2016·Environmental Research·Reginald QuansahSamuel Afful
Oct 3, 2014·Social Studies of Science·Ben W Brisbois
Nov 24, 2016·Thorax·Beyene NegatuRoel Vermeulen
Jun 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Ali MamaneGhislaine Bouvier
Dec 3, 2009·The Journal of Toxicological Sciences·Ana Cristina Rodrigues LacerdaCândido Celso Coimbra
Mar 21, 2012·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Joan B SorianoJulio Ancochea
Oct 6, 2019·The International Journal of Occupational and Environmental Medicine·Nuruly MyzabellaAlison Reid
Apr 19, 2019·Industrial Health·Sonia Díaz-CriolloMarcela E Varona-Uribe
Jul 29, 2020·Archives of Environmental & Occupational Health·José Martim Marques SimasMaria do Carmo Baracho de Alencar
Sep 4, 2015·Biomolecules & Therapeutics·Yeo Jin JangDae Kyong Kim
Feb 9, 2011·Journal of Immunotoxicology·Bamdad RiahiGholamreza Karimi
Aug 31, 2019·International Journal of Environmental Research and Public Health·Yasmin CypelAaron I Schneiderman
Jul 18, 2018·American Journal of Respiratory and Critical Care Medicine·Bo LundbäckPeter M A Calverley
Jan 11, 2012·International Journal of Immunopathology and Pharmacology·N PaolilloS Nisticò
May 9, 2014·Human & Experimental Toxicology·G-L HongZ-Q Lu
Mar 29, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T P ChaoV Z Dourado
Mar 6, 2021·Archives of Environmental & Occupational Health·Sutthinee SidthilawSupakit Khacha-Ananda
Mar 4, 2021·Thorax·Md Omar FaruqueJudith M Vonk
Dec 21, 2007·Journal of Agricultural and Food Chemistry·Eun-Kee ParkBruce D Hammock