Pulmonary function changes in experimental graft-versus-host disease of the lung

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
S MiklosGerhard C Hildebrandt

Abstract

Pulmonary graft-versus-host disease (p-GVHD) is a serious complication after allogeneic stem cell transplantation (allo-SCT) of high morbidity and high mortality. We characterized breathing patterns and pulmonary function changes in correlation to lung histopathology and survival by using a well-established murine model of p-GVHD. Lethally irradiated B6D2F1 mice received SCT from either syngeneic B6D2F1 or allogeneic C57BL/6 animals. Within 6 weeks, severe p-GVHD developed in allogeneic recipients characterized by progressive interstitial, alveolar, peribronchial, and periluminal inflammatory cell infiltration, whereas in syngeneic recipients lung histology remained normal. Allogeneic recipients demonstrated decreased minute ventilation (MV), reduced peak inspiratory and expiratory flow rates as early as 1 week after SCT. In addition, allo-SCT resulted in restrictive pulmonary function changes as early as 7 days after transplantation and in progressive airflow obstruction within 6 weeks. Decreased breathing abilities and pulmonary function changes of allogeneic recipients were associated with increased mortality and the severity of acute graft-versus-host disease (aGVHD). These findings show that p-GVHD can be characterized by ...Continue Reading

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Citations

May 3, 2011·American Journal of Respiratory and Critical Care Medicine·Angela Panoskaltsis-MortariUNKNOWN American Thoracic Society Committee on Idiopathic Pneumonia Syndrome
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sabarinath Venniyil RadhakrishnanGerhard C Hildebrandt

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