PMID: 9544891Apr 17, 1998Paper

Pulmonary function in hospitalized infants and toddlers with cystic fibrosis

The Journal of Pediatrics
R G ClaytonJ L Allen

Abstract

In older children with cystic fibrosis (CF), well-documented improvements in lung function occur during hospitalization for treatment of pulmonary exacerbations. (1) To test the hypothesis that improvement in lung function occurs in infants and toddlers hospitalized because of CF pulmonary exacerbations. (2) To compare changes in lung function measured during forced expiratory flow and tidal breathing. Seventeen infants and toddlers with CF were evaluated at the beginning and end of hospitalization by the rapid thoracic compression technique to yield maximal flow at forced residual capacity. Tidal mechanics were measured by the esophageal balloon technique to yield lung conductance and compliance. Lung function improved during the course of hospitalization. The greatest change was observed in measurements of maximal flow at functional residual capacity (.VmaxFRC), increasing from 38.5% +/- 6% predicted (mean +/- SEM) to 59.8% +/- 6% at the end (p < 0.005). Lung conductance (GL) increased from 60% +/- 6% to 78% +/- 8% (p < 0.02); lung compliance (CL) increased from 66% +/- 5% to 75% +/- 5% (p < 0.03). The degree of improvement of .VmaxFRC, GL, and CL was related to baseline measurements; those with poorer pulmonary function at b...Continue Reading

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Citations

Feb 17, 2010·Journal of Clinical Psychology in Medical Settings·Avani C ModiJamie Wooldridge
Feb 26, 2004·Paediatric Respiratory Reviews·Monika Gappa
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Carolyn J DakinRichard L Henry
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Sarath C RanganathanJanet Stocks
Jul 27, 2007·Proceedings of the American Thoracic Society·Stephanie D DavisMargaret Rosenfeld
Oct 20, 2011·Pediatric Pulmonology·Jessica E PittmanStephanie D Davis
Jun 1, 2008·Expert Review of Respiratory Medicine·Clement L Ren
Jun 2, 2004·Pediatric Pulmonology·Dubhfeasa M SlatteryRobert H Cleveland
Jun 14, 2003·Current Opinion in Pediatrics·Daniel J WeinerHoward B Panitch
Nov 17, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Charlie McLeodThomas L Snelling

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