PMID: 3769370Nov 1, 1986Paper

Pulmonary function in older children and young adults with gastroesophageal reflux

Clinical Pediatrics
J L Allen, M E Wohl

Abstract

A wide variety of types of pulmonary diseases and respiratory symptoms have been associated with gastroesophageal reflux (GER). Asthma, chronic bronchitis, bronchiectasis, and pulmonary fibrosis have all been linked to GER, but causal mechanisms have been difficult to establish. To characterize pulmonary function abnormalities in older children and young adults (age 7-23 years) with GER, lung function was evaluated in 22 patients being treated for reflux. The patients were divided into two groups: nine subjects (Group 1) had no history of pulmonary symptoms. Thirteen subjects (Group 2) had known pulmonary disease; all had diagnosed asthma, and five had a history of recurrent pneumonia. Lung volumes and spirometry were measured. Airway reactivity was assessed by measuring change in flows following isocapneic hyperventilation of subfreezing air. The presence of "small airway" disease was assessed by air-helium flow volume curves and the single breath oxygen test. Lung size, as indicated by measurement of total lung capacity, was normal in all patients. Flow rates, density dependence of maximal expiratory flow, single breath oxygen test, and tests of airway reactivity were abnormal only in Group 2 patients and were normal in the G...Continue Reading

References

Jul 1, 1979·The Journal of Pediatrics·D W Milligan, H Levison
Dec 1, 1972·Journal of Applied Physiology·A MansellH Levison
Aug 1, 1973·American Journal of Surgery·L I IversonP C Samson
May 1, 1971·Thorax·J E Pearson, R S Wilson
May 1, 1971·Journal of Applied Physiology·A Bouhuys, K P Van de Woestijne
May 1, 1966·Diseases of the Chest·R H Overholt, R J Voorhees
May 1, 1984·The Journal of Allergy and Clinical Immunology·H S Nelson
Jun 1, 1982·The Journal of Allergy and Clinical Immunology·H S SpauldingD E Gremillion
Feb 1, 1980·Journal of Pediatric Surgery·J Boix-OchoaJ M Gil-Vernet
Nov 1, 1961·The Journal of Pediatrics·C D COOK, J F HAMANN

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Citations

Jan 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·Y Vandenplas
Nov 1, 1991·Archives of Disease in Childhood·A Malfroot, I Dab
Sep 1, 1990·Chest·E F Geppert
Jun 1, 1988·The Journal of Pediatrics·S R Orenstein, D M Orenstein
Aug 1, 1997·The Journal of Pediatrics·M A LeongJ L Allen
Jul 1, 1992·Pediatric Pulmonology·L E KurlandskyF S Stockinger
Aug 1, 1991·Journal of Paediatrics and Child Health·R N Justo, P H Gray
Jul 1, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·G BrunoP Andreozzi
May 7, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M CinquettiG Zoppi
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·I Dab, A Malfroot

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