PMID: 3769567Nov 1, 1986

Pulmonary function in young insulin-dependent diabetic subjects

M SandlerR I Stewart


To clarify the issue of pulmonary dysfunction in diabetes mellitus, lung mechanics and CO transfer were investigated in 22 young (mean age 19.5 +/- 5 years) non-smoking, insulin-dependent diabetic patients and an equal number of matched healthy subjects. Mean closing capacity/total lung capacity (CC/TLC) was significantly greater in the diabetic than in the control group (31.4 +/- 6.8 vs 27.2 +/- 2.9 percent, p less than 0.01), as was the mean value of the volume independent index of lung elasticity (exponent constant, Kst(L)) (0.148 +/- 0.045 vs 0.118 +/- 0.030, p less than 0.05). The transfer factor expressed per unit alveolar volume (TL/VA) was also significantly lower in the diabetic than in the control group (5.25 +/- 0.68 vs 5.61 +/- 0.57 ml/min/mm Hg/L, p less than 0.05) and this could be ascribed to a lower pulmonary capillary blood volume. There was evidence of mildly abnormal lung mechanics and/or a decreased pulmonary capillary blood volume in 16 (73 percent) of the diabetic group. Since pulmonary dysfunction was either an isolated non-endocrine finding or was associated with only early systemic complications in these young patients, our findings suggest that pulmonary dysfunction is an early measurable complication ...Continue Reading


Sep 1, 1991·Annals of Nuclear Medicine·K UchidaT Ashitaka
Nov 27, 2004·Diabetologia·M P VillaR Ronchetti
Dec 31, 2002·Archives of Medical Research·Mary S BoulbouPaschalis A Molyvdas
Jul 10, 2007·Diabetes Technology & Therapeutics·Connie C W Hsia, P Raskin
Sep 28, 2010·Exercise and Sport Sciences Reviews·James C Baldi, Paul L Hofman
Jun 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·D HeimerH Bark
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·Carlos E MillaA Moran
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·Carlos Pérez-GuzmánMario H Vargas
Jan 1, 1988·The American Review of Respiratory Disease·A F OfulueW M Thurlbeck
Aug 1, 1988·The American Review of Respiratory Disease·A F Ofulue, W M Thurlbeck
Jan 1, 1991·The American Review of Respiratory Disease·T WankeK Irsigler
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Marco GuazziMaurizio D Guazzi
Sep 3, 2011·Lung India : Official Organ of Indian Chest Society·Carlos Pérez-Guzmán, Mario H Vargas
Feb 9, 2010·Medicine and Science in Sports and Exercise·James C BaldiEric M Snyder
Dec 23, 2006·Expert Opinion on Drug Delivery·Rucha JaniRalph A Defronzo
Mar 30, 2010·Chest·Bram van den BorstAnnemie M W J Schols
Jul 1, 1989·Mayo Clinic Proceedings·L A HansenT V Colby
Jan 3, 2012·Paediatric Respiratory Reviews·Carlos E Milla, Jacquelyn Zirbes
Dec 7, 2010·Diabetes Research and Clinical Practice·K KuziemskiJ M Słomiński
Oct 23, 2010·Revue des maladies respiratoires·M-H Becquemin, J-P Chaumuzeau
Oct 3, 2008·Diabetes & Metabolism·A TiengoA Avogaro
May 1, 1990·Respiratory Medicine·B G CooperG J Gibson
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Junling YangLu Cai
Oct 1, 1994·Diabetes Research and Clinical Practice·F InnocentiG Seghieri
Mar 1, 1988·The Journal of Pediatrics·S M FinkelsteinD J Klein
Mar 5, 2005·The American Journal of Medicine·Connie C W Hsia, P Raskin
Jan 16, 1998·The American Journal of Medicine·V NiranjanC C Hsia
Aug 13, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·B N ConwayW J Blot
Jan 8, 2004·Endocrine Journal·Nilgun GuvenerAdnan Gokcel
Nov 23, 2012·Diabetes·Sanjay Rajagopalan, Robert D Brook
Feb 15, 2001·International Journal of Epidemiology·L Dow, S Ebrahim
Mar 8, 2003·American Journal of Respiratory and Critical Care Medicine·Robert E WalterDaniel J Gottlieb
Mar 9, 2018·Frontiers in Endocrinology·Kayani KayaniHasan Mohiaddin

Related Concepts

Expiratory Airflow
Carbon Monoxide
Pulmonary Gas Exchange
Endocrine System
Surfactant Metabolism Dysfunction, Pulmonary,1
Lung Diseases
Lung Compliance

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.