Pulmonary function, muscle strength, and incident mobility disability in elders.

Proceedings of the American Thoracic Society
Aron S BuchmanDavid A Bennett

Abstract

Muscle strength, including leg strength and respiratory muscle strength, are relatively independently associated with mobility disability in elders. However, the factors linking muscle strength with mobility disability are unknown. To test the hypothesis that pulmonary function mediates the association of muscle strength with the development of mobility disability in elders, we used data from a longitudinal cohort study of 844 ambulatory elders without dementia participating in the Rush Memory and Aging Project with a mean follow-up of 4.0 years (SD = 1.39). A composite measure of pulmonary function was based on spirometric measures of forced vital capacity, forced expiratory volume, and peak expiratory flow. Respiratory muscle strength was based on maximal inspiratory pressure and expiratory pressure and leg strength based on hand-held dynamometry. Mobility disability was defined as a gait speed less than or equal to 0.55 m/s based on annual assessment of timed walk. Secondary analyses considered time to loss of the ability to ambulate. In separate proportional hazards models which controlled for age, sex, and education, composite measures of pulmonary function, respiratory muscle strength, and leg strength were each associate...Continue Reading

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Citations

Jan 6, 2011·JAMA : the Journal of the American Medical Association·Stephanie StudenskiJack Guralnik
Mar 30, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Todd M Manini, Brian C Clark
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Nov 9, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L RossoAnne B Newman
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Apr 23, 2014·Rejuvenation Research·Renato GiuaRaffaele Antonelli Incalzi
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Jan 19, 2021·The Journal of Physiology·Ravi A KumarLeonardo F Ferreira
Aug 18, 2021·Journal of Racial and Ethnic Health Disparities·Brittney S Lange-MaiaLisa L Barnes

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