Abstract
Beta-thalassaemia is the most common hemoglobinopathies in our region with treatment of regular blood transfusion. Iron overload and hemosiderosis can cause organ involvement. Recent studies have focused on pulmonary involvement and pathophysiology of lung damage. The goal of this study was to investigate the pulmonary abnormalities in thalassemic patients in relation with sign and symptoms and iron overload. The authors studied pulmonary function test (PFT) at the Adult Thalassemia Clinic in Tehran. The history of blood transfusion, iron chelation, respiratory problems, and drug usage was taken. Physical examination, PFT, arterial blood gas (ABG), and chest X-ray (CXR) were done. In total, 139 patients were studied. The mean age was 21.1 years and mean duration of transfusion was 18 years. It was found that 133 patients (95.7%) did not have respiratory problems and only 6 (4.3%) had some respiratory complaints. In CXR, 100 patients (89.3%) had normal lung pattern and others (10.7%) had variable degrees of abnormal lung pattern. In ABG, mean of Po(2) was 73.5% and mean of O(2) saturation was 90.6%. In PFT, 101 patients (72.7%) had restrictive pattern, 35 (25.1%) had normal pattern, and 3 (2.2%) had combined pattern. According t...Continue Reading
References
Feb 1, 1992·Chest·A BacaloM Topilsky
Nov 1, 1991·The American Review of Respiratory Disease
Aug 1, 1974·Journal of Clinical Pathology·E A LetskyD M Flynn
Dec 15, 1966·The New England Journal of Medicine·P A Marks
Sep 1, 1994·Pediatric Pulmonology·F SantamariaR Ronchetti
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·J M FactorP J Giardina
Jan 1, 1993·Pediatric Hematology and Oncology·D K LuytS G Reinach
Jul 1, 1996·The European Respiratory Journal·D Y TaiH K Cheng
Dec 24, 1998·The European Respiratory Journal·C CracowskiP Lévy
May 8, 1999·The European Respiratory Journal·I DimopoulouG E Tzelepis
Jul 20, 2000·European Journal of Haematology·N KanjA Taher
Aug 3, 2000·The New England Journal of Medicine·E AngelucciG Lucarelli
May 8, 2001·Indian Journal of Pediatrics·M AroraA K Dutta
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·A FilosaR Cassandro
Aug 22, 2001·Thorax·E ZakynthinosS G Zakynthinos
Oct 18, 2001·Seminars in Hematology·D Rund, E Rachmilewitz
Oct 18, 2001·Seminars in Hematology·B Wonke
Sep 24, 2002·Archives of Disease in Childhood·A M LiT F Fok
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Vittorio CarnelliEdgardo D'Angelo
Jul 1, 2006·Acta Haematologica·G PiattiM D Cappellini
Mar 16, 2007·Journal of Pediatric Hematology/oncology·Ankit ParakhHarmanjeet Singh Hira
Apr 10, 2007·Chronic Respiratory Disease·F M Abu-EkteishI M Shehabi
Citations
Oct 4, 2013·Pediatric Hematology and Oncology·Ahmed El Saiid HamedAlia Osama Ali Abd-El-Gawad
Oct 23, 2012·Asian Cardiovascular & Thoracic Annals·Noor Mohammad NooriMosaeib Shahriar
Feb 20, 2019·Transfusion Medicine·A A Abd El HakeemS S Abd El Azeim
Oct 1, 2015·Journal of Pediatric Hematology/oncology·Derya Ozyoruk, Emine D Misirlioglu
Jul 30, 2014·The Clinical Respiratory Journal·Bora GülhanNural Kiper
Feb 25, 2011·Pediatric Hematology and Oncology·Soheila AlyasinMehran Karimi
Feb 14, 2012·Pediatric Pulmonology·Evangelia BourliVictor Aivazis