PMID: 3125012Mar 1, 1988Paper

Pulmonary function tests cannot predict exercise-induced hypoxemia in chronic obstructive pulmonary disease

Chest
A L RiesJ L Clausen

Abstract

We studied 40 patients with chronic obstructive pulmonary disease (COPD) to determine whether measurements of pulmonary function could predict a fall in arterial oxygen pressure (PaO2) with exercise. The PaO2 fell more than 3 mm Hg in 21 patients (group 1), did not change (+/- 3 mm Hg) in nine patients (group 2), and increased more than 3 mm Hg in ten patients (group 3). Group 3 had significantly less severe expiratory obstruction than groups 1 and 2. The most significant variables in predicting a change in PaO2 with exercise were the ratio of the forced expiratory volume in one second over the forced vital capacity (FEV1/FVC) and the single-breath carbon monoxide diffusing capacity (Dsb). Measurements of FEV1/FVC of 0.50 or more and Dsb of 20 ml/min/mm Hg or more were 100 percent predictive in excluding a fall in PaO2 with exercise. Measurements below these thresholds could not be used reliably to predict which patients would develop worsening hypoxemia with exercise. Because of wide variability in reference values from eight different published studies for diffusing capacity, recommended criteria based on the percent predicted Dsb should be used with caution. We conclude that pulmonary function measurements cannot be used to ...Continue Reading

References

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Citations

Mar 24, 2009·Clinical Reviews in Allergy & Immunology·Cristine E Berry, Robert A Wise
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·American Thoracic Society, American College of Chest Physicians
Jan 23, 2002·Journal of Occupational and Environmental Medicine·Gershon FinkMordechai R Kramer
Apr 6, 2005·Medicine and Science in Sports and Exercise·Melissa R MazanAndrew Hoffman
Nov 27, 2009·COPD·Ralph J Panos, William Eschenbacher
Mar 8, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shawn K Ahlfeld, Simon J Conway
Oct 24, 2006·Respiratory Medicine·David A KaminskyPeter W Callas
Jul 1, 1996·Respiratory Medicine·N Ambrosino, K Foglio
Aug 1, 1996·Respiratory Medicine·N Ambrosino, E Clini
Jun 8, 2017·Annals of the American Thoracic Society·Susan A WardDenny Z H Levett
Nov 18, 2003·Clinical Physiology and Functional Imaging·Toru HiragaTakeshi Ogura

Related Concepts

Anoxemia
Carbon Dioxide
Dyspnea
Cardiopulmonary Exercise Test
Lassitude
Lung
Lung Diseases, Obstructive
Dioxygen
Respiratory Function Tests

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