Pulmonary function tests in beta thalassemia

Indian Journal of Pediatrics
M AroraA K Dutta

Abstract

To study pulmonary function tests (PFT) in multiple transfusion recipient thalassemics, PFTs were done for 30 thalassemics and 20 matched controls. Confirmed cases of thalassemia on regular transfusion therapy were the subject of study. Apart from history and physical examination of the thalassemics, serum ferritin estimation and spirometry were done. Parameters studied included lung volumes--functional residual capacity (FRC), forced vital capacity (FVC), residual volume (RV) and total lung capacity (TLC); and flow rates--forced expiratory volume in one second (FEV1), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC), peak expiratory flow 25-75 (PEF 25-75%) and peak expiratory flow rate (PEFR). Single breath carbon monoxide diffusing capacity (DLco) and arterial blood gas (ABG) were also analysed. The mean height and weight of thalassemics were below that of age matched controls. A restrictive abnormality in PFT was found in 86.6% cases. These patients were found to have a decrease in all the lung volumes namely FVC, FRC, RV and TLC with a proportional decrease in the flow rates, FEV1, PEF 25-75% and PEF with a normal (> 0.75) FEV1/FVC ratio. DLco was decreased in all the patients with restrictive lung dise...Continue Reading

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Citations

May 1, 1994·European Journal of Radiology·C OrzincoloP N Scutellari
Mar 16, 2007·Journal of Pediatric Hematology/oncology·Ankit ParakhHarmanjeet Singh Hira
Mar 6, 2016·Indian Journal of Pediatrics·Raviraj PurohitJaykaran Charan
Oct 1, 2015·Journal of Pediatric Hematology/oncology·Derya Ozyoruk, Emine D Misirlioglu
Feb 14, 2012·Pediatric Pulmonology·Evangelia BourliVictor Aivazis
Oct 4, 2013·Pediatric Hematology and Oncology·Ahmed El Saiid HamedAlia Osama Ali Abd-El-Gawad
Apr 10, 2007·Chronic Respiratory Disease·F M Abu-EkteishI M Shehabi
Feb 20, 2019·Transfusion Medicine·A A Abd El HakeemS S Abd El Azeim
Sep 9, 2006·Epidemiology and Infection·A R RenwickR G Bengis
Aug 30, 2008·Pediatric Hematology and Oncology·Azita AzarkeivanParvaneh Vosough
Feb 25, 2011·Pediatric Hematology and Oncology·Soheila AlyasinMehran Karimi

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