Pulmonary function with expiratory resistive loading in healthy volunteers.

PloS One
Jyotika ErramDaniel T Cannon

Abstract

Expiratory flow limitation is a key characteristic in obstructive pulmonary diseases. To study abnormal lung mechanics isolated from heterogeneities of obstructive disease, we measured pulmonary function in healthy adults with expiratory loading. Thirty-seven volunteers (25±5 yr) completed spirometry and body plethysmography under control and threshold expiratory loading of 7, 11 cmH2O, and a subset at 20 cmH2O (n = 11). We analyzed the shape of the flow-volume relationship with rectangular area ratio (RAR; Ma et al., Respir Med 2010). Airway resistance was increased (p<0.0001) with 7 and 11 cmH2O loading vs control (9.20±1.02 and 11.76±1.68 vs. 2.53± 0.80 cmH2O/L/s). RAR was reduced (p = 0.0319) in loading vs control (0.45±0.07 and 0.47±0.09L vs. 0.48±0.08). FEV1 was reduced (p<0.0001) in loading vs control (3.24±0.81 and 3.23±0.80 vs. 4.04±1.05 L). FVC was reduced (p<0.0001) in loading vs control (4.11±1.01 and 4.14±1.03 vs. 5.03±1.34 L). Peak expiratory flow (PEF) was reduced (p<0.0001) in loading vs control (6.03±1.67 and 6.02±1.84 vs. 8.50±2.81 L/s). FEV1/FVC (p<0.0068) was not clinically significant and FRC (p = 0.4) was not different in loading vs control. Supra-physiologic loading at 20 cmH2O did not result in further l...Continue Reading

References

Jun 1, 1970·Journal of Applied Physiology·R E MuellerG F Filley
Feb 1, 1995·The European Respiratory Journal·N G KoulourisJ Milic-Emili
Jan 1, 1995·Respiration; International Review of Thoracic Diseases·K WassermannH E Eckel
May 1, 1996·Journal of Applied Physiology·J A Spahija, A Grassino
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·L EltayaraJ Milic-Emili
Jul 10, 1998·The European Respiratory Journal·C F MelissantM Demedts
Apr 19, 2002·Journal of Applied Physiology·Iacopo IandelliAntonio Pedotti
Apr 19, 2002·Journal of Applied Physiology·Andrea AlivertiPeter T Macklem
Mar 28, 2006·Proceedings of the American Thoracic Society·Denis E O'Donnell
May 17, 2006·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·David BellamySonia Buist
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andrea AlivertiPeter T Macklem
Jan 23, 2008·Respiratory Research·Claudio TerzanoAngelo Petroianni
Feb 5, 2008·Respiratory Medicine·Lisette van den BemtChris van Weel
Dec 17, 2008·Respiratory Medicine·Christopher B Cooper
Jan 7, 2011·Chest·Yvonne Nussbaumer-Ochsner, Klaus F Rabe
Nov 16, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Milla KatajistoTarja Laitinen
Feb 11, 2014·Clinics in Chest Medicine·Denis E O'DonnellJ Alberto Neder
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Jul 1, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Aleksander E MakarevichMichail Nedvedz
Aug 28, 2014·Expert Review of Respiratory Medicine·Daniel LangerDenis E O'Donnell
Aug 31, 2014·Annals of the American Thoracic Society·Michael EberleinRoy G Brower
Dec 2, 2014·COPD·Esther Barreiro, Joaquim Gea
Jan 24, 2016·BMC Pulmonary Medicine·Jungsil LeeUNKNOWN KOLD Study Group
Nov 5, 2016·Respiratory Physiology & Neurobiology·Janos VargaJanos Porszasz
Feb 14, 2018·Respiratory Physiology & Neurobiology·Janos PorszaszRichard Casaburi

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