Pulmonary gangliocytic paraganglioma: case report and comparative immunohistochemical study of related neuroendocrine neoplasms

The American Journal of Surgical Pathology
M HironakaN Funata

Abstract

The authors report a case of gangliocytic paraganglioma of the lung, which has not yet been described in a pulmonary neoplasm. A 75-year-old man underwent right middle and lower lobe lobectomy. A slightly yellowish mass was located at the bifurcation between the lower and middle lobe bronchus, protruding into the truncus intermedius. The neoplastic cells were composed of three cellular elements: uniform endocrine cells in a Zellballen arrangement, large ganglion-like cells within the nests of endocrine cells, and spindle-shaped cells arranged in streams to surround the nests. Each component exhibited the characteristic immunohistochemical properties, which were similar to those of the corresponding neuroendocrine neoplasms: Endocrine cells were positive for CAM 5.2, chromogranin A, and synaptophysin, like carcinoid tumor; ganglion-like cells were positive only for neurofilament, like ganglioneuroma; and spindle-shaped cells were positive for neurofilament and S-100 protein, like paraganglioma. These results agreed with those in gangliocytic paraganglioma of the duodenum. Pulmonary gangliocytic paraganglioma is similar to that in the duodenum, and is a hamartomatous proliferation of epithelial endocrine and neuronal cells of the...Continue Reading

References

Sep 1, 1977·The American Journal of Surgical Pathology·R J ReedJ C Harkin
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M BarbareschiM Falleni
Jul 1, 1989·American Journal of Clinical Pathology·A P Burke, E B Helwig
Nov 1, 1986·American Journal of Clinical Pathology·B W ScheithauerJ A Carney
Feb 1, 1989·Thorax·J R HangartnerJ R Pepper
Aug 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M FukayamaH Okumura
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KawaguchiN Goseki
May 1, 1967·Journal of Clinical Pathology·F J Fawcett, E M Husband
Jan 1, 1969·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E LaustelaK Franssila
Jan 1, 1972·Journal of Surgical Oncology·Y T Lee, J M Hori
Jan 1, 1972·Chest·M L Goodman, E G Laforet
May 1, 1966·Thorax·H MosteckýM Kalus
Apr 1, 1958·The Journal of Pathology and Bacteriology·A G HEPPLESTON

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Citations

Jul 27, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Agnes WitkiewiczSamuel D Gross
Dec 25, 2009·Medical Molecular Morphology·Yuji OhtsukiMutsuo Furihata
Nov 15, 2011·European Journal of Gastroenterology & Hepatology·Maximilien BarretAnne Berger
Apr 11, 2003·Pathology International·Kuniko IiharaSumiko Uno
Sep 26, 2003·The American Journal of Surgical Pathology·Ai-Rene KeeRoss J Glancy
Nov 16, 2011·ISRN Surgery·Fazl Q ParrayNatasha Thakur
May 24, 2011·BMC Cancer·Yoichiro OkuboNobuyuki Hiruta
May 29, 2004·The American Journal of Surgical Pathology·Junji ShibaharaMasashi Fukayama
Jan 18, 2017·Gastroenterology Research and Practice·Yoichiro OkuboYoichi Kameda
Mar 25, 2020·Journal of Bronchology & Interventional Pulmonology·Yasunori KaminumaHiroshi Niwa
Jul 25, 2003·Annales de chirurgie·C HenryH Moindrot
Oct 20, 2004·Human Pathology·David M WeinrachWilliam B Laskin
Dec 26, 2003·Seminars in Diagnostic Pathology·Mark R Wick, Oscar Nappi
Jun 10, 2005·Annals of Diagnostic Pathology·Jose Antonio PlazaWilliam L Marsh
Jul 28, 2005·Gastrointestinal Endoscopy·Victor NwakakwaPaul Yeaton
Nov 3, 2010·Annals of Diagnostic Pathology·Corwyn RowsellRunjan Chetty

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