Pulmonary gas exchange effects by nitroglycerin, dopamine and dobutamine during one-lung ventilation in man

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Y Nomoto, M Kawamura

Abstract

The effects of nitroglycerin, dopamine and dobutamine on pulmonary gas exchange were determined in 21 adult patients during two-lung and one-lung ventilation. Nitroglycerin, in 1 microgram.kg-1.min-1, decreased cardiac index (CI) and PaO2 during both two- and one-lung ventilation, and increased in Qs/Qt during one-lung ventilation. There were no significant changes in the measured variables during infusion of dopamine, 5 microgram.kg-1.min-1. Dobutamine, 5 microgram.kg-1.min-1, increased CI and PaO2 did not change during two-lung ventilation. During one-lung ventilation, PaO2 increased from (mean value +/- SD) 168 +/- 46 to 201 +/- 52 mmHg (P less than 0.01) with dobutamine infusion. Qs/Qt decreased from 29.2 +/- 7.0 to 26.0 +/- 6.2 per cent (P less than 0.05) without any change in pulmonary vascular resistance index during one-lung ventilation. We conclude that dobutamine has advantages over dopamine and nitroglycerin during one-lung ventilation.

References

Feb 1, 1977·Anesthesiology·J MathersE A Wahrenbrock
Apr 1, 1979·British Journal of Anaesthesia·J L MarinM K Sykes
Aug 1, 1977·Intensive Care Medicine·B RegnierA Harari
Aug 1, 1975·The American Journal of Cardiology·N AkhtarM H Chaudhry
Apr 1, 1976·Circulation Research·A P Fishman
Aug 1, 1985·Acta Anaesthesiologica Scandinavica·J StrømM Bredgaard Sørensen
Oct 1, 1983·Annals of Internal Medicine·C V Leier, D V Unverferth
Aug 1, 1981·Anesthesiology·P S ColleyM P Hlastala
May 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R GrahamH S Goldberg
Jun 1, 1983·Acta Anaesthesiologica Scandinavica·H Tydén, S O Nyström
Jun 1, 1982·British Journal of Anaesthesia·C H OrchardM K Sykes
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G H ParsonsJ D Goldstein
Feb 1, 1980·Cardiovascular Research·H Morishita, T Furukawa

❮ Previous
Next ❯

Citations

Nov 17, 2009·Der Anaesthesist·S HaasD A Reuter
Jul 1, 2010·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Gang WangTingting Chen
Jan 16, 2008·Current Opinion in Anaesthesiology·Andrew Ian LevinAndre Coetzee
Dec 24, 2004·Anesthesia and Analgesia·Andrew I Levin, Johan F Coetzee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.