PMID: 9547440Apr 21, 1998Paper

Pulmonary hemodynamics and endothelin levels in pacing-induced heart failure: during rest and exercise

Journal of Cardiac Failure
S B KribbsF G Spinale

Abstract

Elevated plasma levels of endothelin (ET) have been reported to accompany the development of heart failure (HF), and therefore, this potent vasoconstrictive peptide has been postulated to contribute to the altered pulmonary hemodynamics that occur in this disease process. The overall goal of this study was to examine more carefully the relationship between ET levels in the pulmonary system and pulmonary hemodynamics in the normal and HF states, during both rest and exercise. This study used a porcine model of chronic rapid pacing that has been shown in previous studies to produce left ventricular dysfunction and neurohormonal system activation consistent with the syndrome of HF. Pigs (n = 10) were chronically instrumented to measure pulmonary and systemic hemodynamics, parenchymal flow, and ET content and to obtain blood samples from the pulmonary circuit in the conscious state. Measurements were performed in the normal control state and again following the development of pacing-induced HF (240 beats/min per 21 days), both at rest and during treadmill exercise (3 mph, 15 degrees incline, 12 minutes). With HF, under ambient resting conditions, a threefold increase in pulmonary plasma ET occurred and was accompanied by a fivefold...Continue Reading

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Citations

Jul 30, 2011·Journal of the American College of Cardiology·Jill Downing, Gary J Balady
May 8, 2018·Postgraduate Medical Journal·Mark Abela
Oct 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yonis AbukarRohit Ramchandra
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H KjekshusH Attramadal

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