Pulmonary hemorrhage associated with Henoch-Schönlein purpura in a child

Clinical Rheumatology
Rie MatsubayashiHideo Enoki

Abstract

Swelling of the right ankle and purpura on the bilateral lower extremities of a 6-year-old boy indicated a diagnosis of Henoch-Schönlein purpura (HSP). The patient was referred to our hospital because of severe abdominal pain that was unresponsive to prednisolone. Respiratory symptoms and pulmonary infiltrates on chest X-ray were absent upon admission. Methylprednisolone pulse therapy gradually improved the abdominal symptoms, but tachypnea developed, and insufficient aeration of the right lung was accompanied by a decline in percutaneous oxygen saturation from 99% to 90% and a rapid decrease in hemoglobin levels from 11.7 to 7.6 g/dL. Chest X-rays and high-resolution computed tomography scans showed widespread consolidation and patchy opacities predominantly in the right lung fields, suggesting acute pulmonary hemorrhage. Intravenous cyclosporin A (CyA) gradually resolved the pulmonary hemorrhage and respiratory insufficiency. Pulmonary hemorrhage, as a complication of HSP, is extremely rare and sometimes fatal. Aggressive steroid and immunosuppressive treatment is required to address severe complications of HSP.

References

Jul 1, 1992·The Journal of Pediatrics·M ChaussainD Gendrel
Feb 1, 1987·Scottish Medical Journal·C D PaytonJ M Boulton-Jones
Mar 1, 1994·Ryōikibetsu shōkōgun shirīzu·T Nagasawa
Apr 1, 1994·Pediatric Pulmonology·W K WrightV M Reznik
Jul 1, 1997·Pediatric Dermatology·A S PallerR Sethi
May 8, 1999·The European Respiratory Journal·S CazzatoE Cacciari
Aug 19, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K R VatsA R Sinaiko
Sep 1, 2001·Clinical Rheumatology·N BesbasA Bakkaloglu
Sep 7, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nafaa N Al-Harbi
Aug 21, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jaana RonkainenMatti Nuutinen
Sep 24, 2005·Rheumatology International·Mukaddes KalyoncuAysenur Okten

❮ Previous
Next ❯

Citations

Sep 19, 2012·Seminars in Arthritis and Rheumatism·Srinivas RajagopalaIsha Garg
Aug 16, 2011·Actas dermo-sifiliográficas·A Pulido-PérezR Suárez-Fernández
Oct 16, 2014·Hospital Pediatrics·Anne NgobiaNdidi I Unaka
Jul 28, 2016·Clinical Rheumatology·Izabela Grabska-KobyleckaPiotr Bialasiewicz
Jun 8, 2018·Internal Medicine·Seigo MiyoshiJitsuo Higaki
Jun 6, 2013·Experimental and Therapeutic Medicine·Xianqing RenXiaoqing Yang
Nov 23, 2019·Pediatric Rheumatology Online Journal·Giada Maria Di PietroClaudia Tagliabue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Rheumatology International
Mukaddes KalyoncuAysenur Okten
Ryōikibetsu shōkōgun shirīzu
T Nagasawa
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
K R VatsA R Sinaiko
© 2021 Meta ULC. All rights reserved