Pulmonary Hypertension and Obesity: Focus on Adiponectin

International Journal of Molecular Sciences
Fabio PerrottaGermano Guerra

Abstract

Pulmonary hypertension is an umbrella term including many different disorders causing an increase of the mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg. Recent data revealed a strong association between obesity and pulmonary hypertension. Adiponectin is a protein synthetized by the adipose tissue with pleiotropic effects on inflammation and cell proliferation, with a potential protective role on the pulmonary vasculature. Both in vivo and in vitro studies documented that adiponectin is an endogenous modulator of NO production and interferes with AMP-activated protein kinase (AMPK) activation, mammalian target of rapamycin (mTOR), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ) signaling preventing endothelial dysfunction and proliferation. Furthermore, adiponectin ameliorates insulin resistance by mediating the biological effects of peroxisome proliferator-activated receptor-gamma (PPARγ). Therefore, adiponectin modulation emerged as a theoretical target for the treatment of pulmonary hypertension, currently under investigation. Recently, consistent data showed that hypoglycemic agents targeting PPARγ as well as renin⁻angiotensin system inhibitors and mineralocorticoid receptor blockers may influen...Continue Reading

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Citations

Jul 3, 2019·International Journal of Molecular Sciences·Antonina OrlandoSimonetta Genovesi
Aug 24, 2019·Frontiers in Oncology·Xiao Yang, Jianliu Wang
Jun 20, 2020·Aging Clinical and Experimental Research·Fabio PerrottaAndrea Bianco
Jul 22, 2019·International Journal of Molecular Sciences·Kamil Jonas, Grzegorz Kopeć
Jul 18, 2020·Obesity Surgery·Ahmed Abdallah SalmanHani Maurice Sabri Mikhail
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May 2, 2020·International Journal of Molecular Sciences·Giovanni MessinaFrancesco Sessa
Dec 4, 2020·Journal of Drug Targeting·Yin-Yu ZhangLi Qin
Feb 5, 2021·International Journal of Molecular Sciences·Aimilia Eirini PapathanasiouHelen Christou
Dec 15, 2020·International Journal of Endocrinology·Ersilia NigroAurora Daniele
Apr 28, 2021·Physiology·Simone C da Silva RosaGary Sweeney
May 4, 2021·Frontiers in Endocrinology·Klara KomiciGermano Guerra
Jun 4, 2021·Toxicology and Applied Pharmacology·Magdalena Jasińska-Stroschein
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang
Jun 16, 2021·Current Opinion in Pulmonary Medicine·Allyson L Hughes, Anna R Hemnes

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