Pulmonary Hypertension in Infants, Children, and Young Adults

Journal of the American College of Cardiology
Georg Hansmann

Abstract

Pulmonary hypertension (PH) in neonates, infants, children, adolescents, and young adults is a complex condition that can be associated with several cardiac, pulmonary, and systemic diseases contributing to morbidity and mortality. The underlying pulmonary hypertensive vascular disease (PHVD) is characterized by inflammation, pulmonary vascular remodeling, and angio-obliteration leading to elevated pulmonary arterial pressure and resistance, right ventricular dysfunction, left ventricular compression, and subsequent heart failure. Recent advancements in PH-targeted therapies and interventional-surgical procedures have contributed to the improvement in quality of life and survival in PH/PHVD. This paper gives an update on recent developments in the diagnosis and treatment of children and young adults with PH. The focus is on the heterogeneous etiology/pathophysiology of PH in the young, and particularly on PHVD associated with congenital heart disease. Moreover, new pharmacological, surgical, and interventional therapies and their practical application in progressive/severe pulmonary arterial hypertension with inadequate response to conventional pharmacotherapy are discussed.

Citations

Nov 11, 2018·Paediatric Anaesthesia·Gregory J Latham, Delphine Yung
Jan 31, 2019·Expert Review of Cardiovascular Therapy·Nesrine FarhatMaurice Beghetti
Apr 28, 2019·Pediatric Exercise Science·Dan M Cooper
Nov 27, 2019·Journal of Veterinary Internal Medicine·Justin AllenAnthony Llamas
Oct 3, 2019·American Journal of Respiratory Cell and Molecular Biology·Georg HansmannStephen Y Chan
May 14, 2020·Expert Opinion on Pharmacotherapy·F Rana Olguntürk
Mar 1, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuan HuangHao Zhang
Jul 25, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philippe ChouvarineGeorg Hansmann
Sep 14, 2019·Annals of Pediatric Cardiology·Paquay StéphanieNassogne Marie-Cécile
Jan 10, 2020·Pediatric Pulmonology·Carrie L WelchWendy K Chung
Feb 29, 2020·Pulmonary Circulation·Abraham RothmanHumberto Restrepo
Oct 2, 2020·Pediatric Pulmonology·Charissa W Kam, Fadel E Ruiz
Oct 22, 2020·Genes·Carrie L Welch, Wendy K Chung
Sep 10, 2019·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Georg HansmannPeter Zartner
Feb 16, 2021·Birth Defects Research·Renata H BenjaminA J Agopian
Jun 17, 2021·CPT: Pharmacometrics & Systems Pharmacology·Rui-Sheng Wang, Joseph Loscalzo
Aug 28, 2021·International Journal of Molecular Sciences·Heber Ivan Condori LeandroEvgeny N Mikhaylov
Sep 9, 2021·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Mário Cícero FalcãoJuliana Zoboli Del Bigio
Apr 27, 2018·Science Translational Medicine·Ekaterina LegchenkoGeorg Hansmann
Oct 24, 2020·Pediatrics·Shannon E G HamrickGeorg Hansmann

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