Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival

The Korean Journal of Internal Medicine
Hong Ki MinSung-Hwan Park

Abstract

We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival. This retrospective single-center study included 154 Korean SLE patients fulfilling the American College of Rheumatology criteria (January 1995 to June 2013). Student t test, Mann-Whitney U test, Kaplan-Meier curves, and log-rank tests were used for comparisons. A total of 35 SLE patients with PH (SLE/PH+) and 119 without PH (SLE/PH-) were analyzed. Higher percentages of interstitial lung disease, Raynaud's phenomenon (RP), World Health Organization functional classification III/IV, and cardiomegaly were found in SLE/PH+ compared to SLE/PH-. Furthermore, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was significantly higher in SLE/PH+ (2.46 ± 1.245 vs. 1.00 ± 1.235), whereas survival rates were significantly higher in SLE/PH- in log-rank tests (p = 0.001). In multivariate analysis, the adjusted mortality hazard ratio (HR) for SLE/PH+ patients was 3.10. Subgroup analysis demonstrated a higher percentage of lupus nephritis in the SLE/PH+ patients who died (p ...Continue Reading

References

Aug 1, 1981·Seminars in Arthritis and Rheumatism·H D Perez, N Kramer
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Sep 9, 2004·Lupus·S R JohnsonJ T Granton
May 31, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stephan Rosenkranz
Aug 13, 2009·Rheumatology·Athiveeraramapandian PrabuCaroline Gordon
Jul 31, 2012·Autoimmunity Reviews·Guillermo Ruiz-IrastorzaCiriaco Aguirre

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Citations

Oct 11, 2017·Current Rheumatology Reports·Hamza JawadSanjeev Bhalla
Jan 19, 2019·Advances in Rheumatology·Juliana Fernandes Sarmento DonnarummaCristiane Kayser
Aug 25, 2018·Case Reports in Rheumatology·Varun JainRichard Sidlow

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