Pulmonary hypertension in Takayasu arteritis

International Journal of Rheumatic Diseases
Alper SariAli Akdoğan

Abstract

To determine the frequency and define the causes of pulmonary hypertension (PH) in patients with Takayasu arteritis (TA). Sixty-four TA patients were evaluated by transthoracic echocardiography (TTE). Having an estimated systolic pulmonary arterial pressure (sPAP) ≥40 mm Hg by echocardiography or if performed, mean PAP ≥25 mm Hg in right heart catheterization was defined as PH. Clinical, imaging and laboratory results of the TA patients were obtained from hospital files. In total, seven (10.9%) patients had PH. Four patients had PH due to left-sided heart disease (group 2 PH), three patients due to pulmonary arterial involvement (PAI; group 4 PH) and one patient due to atrial septal defect (group 1 PH). In one patient, combination of PAI, aortic insufficiency and pulmonary venous return anomaly was present and he was considered to have both group 2 and group 4 PH. PAI was more frequent (42.9% vs 15.7%) in patients with PH but the difference was not statistically significant. The percentage of patients treated with cyclophosphamide and/or biologics was higher in the group with PH as compared to the group without PH (P = 0.015). One patient with group 4 PH had been on pulmonary arterial hypertension (PAH)-specific agents for 8 ye...Continue Reading

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Citations

Jun 24, 2019·European Heart Journal Cardiovascular Imaging·Leyla Elif Sade, Ali Akdogan
May 17, 2019·The Journal of Rheumatology·Yanru HeNan Cheng
Aug 29, 2020·Current Rheumatology Reports·Luis H Silveira
Jul 20, 2019·Current Rheumatology Reports·Maria L F Zaldivar VillonLuis R Espinoza
May 23, 2021·Clinical Rheumatology·Yu-Jiao WangLin-Di Jiang

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