Pulmonary hypertension in thalassaemia major patients with normal left ventricular systolic function

British Journal of Haematology
R W HagarE P Vichinsky

Abstract

Pulmonary hypertension is common in adults with thalassaemia and other haemolytic anaemias. It was hypothesised that regular transfusions in thalassaemia major should both decrease the chronic haemolytic rate and be protective from pulmonary hypertension (PHT). To reduce the contribution of existing cardiac disease to PHT, the subjects were limited to patients with normal left ventricular shortening fractions. Associations with multiple laboratory markers of haemolysis, serum ferritin levels, chest X-rays findings and splenectomy status were also considered. We found no biochemical, transfusional, or clinical (except gender) differences in transfused thalassaemia patients with or without pulmonary hyper tension.

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Citations

Mar 1, 2012·Annals of Hematology·Samy B M El-HadyMohammad A Elhady
Jan 17, 2014·The Lancet. Respiratory Medicine·Anastasia AnthiApostolos Armaganidis
Mar 27, 2012·American Journal of Respiratory and Critical Care Medicine·Andrew C Miller, Mark T Gladwin
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Apr 16, 2013·Haematologica·Claudia R MorrisUNKNOWN Thalassemia Clinical Research Network
Nov 26, 2013·Clinics in Chest Medicine·Roberto F Machado, Harrison W Farber
Mar 18, 2008·British Journal of Haematology·Ward Hagar, Elliott Vichinsky
Aug 18, 2010·Annals of the New York Academy of Sciences·Claudia R Morris, Elliott P Vichinsky
Jan 10, 2014·European Journal of Haematology·Nattiya TeawtrakulSuporn Chuncharunee
Mar 24, 2016·Annals of the New York Academy of Sciences·Dustin R Fraidenburg, Roberto F Machado
Dec 10, 2014·Blood Cells, Molecules & Diseases·Antonella MeloniJohn C Wood
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Apr 9, 2016·Annals of the American Thoracic Society·Lucas M Kimmig, Harold I Palevsky
Dec 11, 2020·PloS One·Ameen M MohammadNasir Al-Allawi

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