Pulmonary hypertension with adult respiratory distress syndrome: prevalence, clinical impact, and association with central venous pressure

Pulmonary Circulation
Dong-Kai LiXiao-Ting Wang

Abstract

Pulmonary hypertension (PH) occurs in patients with acute respiratory distress syndrome (ARDS); the most severe form comprises acute cor pulmonale (ACP). Here, we investigated the prevalence of PH in patients with ARDS to evaluate its correlation with ACP risk, ARDS severity and central venous pressure (CVP). We conducted a secondary analysis using data from the MIMIC-III open-source clinical database. The prevalence of PH associated with new-onset ARDS during the first 72 h after intensive care unit admission was investigated; moreover, the association between ACP risk score and PH was validated. We also evaluated the association between elevated CVP (mean CVP > 10 mmHg) and PH and other clinical outcomes. Among 2434 patients who met the ARDS Berlin criteria and underwent echocardiography or pulmonary artery catheterization evaluation, a total of 583 (24.0%) patients were diagnosed with moderate or severe PH, of which 418 had low and 165 had high ACP risk. After adjustment for disease/ARDS severity, ACP risk score, and other demographic variables, elevated CVP was independently associated with the occurrence of PH (odds ratio, 2.239 (1.674, 2.993), p < 0.005). Among patients with PH, higher mean CVP was associated with prolong...Continue Reading

Associated Datasets

References

Jan 30, 2007·Journal of Intensive Care Medicine·Sheldon Magder, Fahad Bafaqeeh
Jun 19, 2010·American Journal of Respiratory and Critical Care Medicine·Todd M BullUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute ARDS Network
Aug 23, 2011·Journal of Critical Care·Allan J Walkey, Renda Soylemez Wiener
Jan 17, 2015·Annals of Intensive Care·Donal RyanPaul McLoughlin
Apr 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·David A Berlin, Jan Bakker
Apr 2, 2016·Critical Care Medicine·Curtis H WeissStephen D Persell
May 25, 2016·Scientific Data·Alistair E W JohnsonRoger G Mark
Aug 4, 2016·Respiratory Care·Alexis PaternotAntoine Vieillard-Baron
Jul 14, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Saurabh Kumar DasAmitabh Lahkar
Dec 29, 2017·Pulmonary Circulation·George CalcaianuRomain Kessler

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Citations

May 21, 2021·Medical Devices : Evidence and Research·Emanuela MarcelliGianni Plicchi
Aug 26, 2021·Chinese Medical Journal·Pan PanUNKNOWN Chinese Critical Ultrasound Study Group (CCUSG)

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Software Mentioned

SPSS® Statistics
MIMIC
SPSS

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