Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Mark Baguma-Nibasheka, Boris Kablar

Abstract

Connective tissue growth factor (CTGF) is a mediator of growth factor activity, and Ctgf knockouts die at birth from respiratory failure due to skeletal dysplasia. Previous microarray analysis revealed Ctgf down-regulation in the hypoplastic lungs of amyogenic mouse embryos. This study, therefore, examined pulmonary development in Ctgf-/- mouse fetuses to investigate if respiration could also have been impaired by lung abnormalities. The Ctgf-/- lungs were hypoplastic, with reduced cell proliferation and increased apoptosis. PDGF-B, its receptor and IGF-I, were markedly attenuated and the TTF-1 gradient lost. Type II pneumocyte differentiation was perturbed, the cells depicting excessive glycogen retention and diminished lamellar body and nuclear size, though able to synthesize surfactant-associated protein. However, type I pneumocyte differentiation was not affected by Ctgf deletion. Our findings indicate that the absence of Ctgf and/or its protein product, CTGF, may induce pulmonary hypoplasia by both disrupting basic lung developmental processes and restricting thoracic expansion.

References

Feb 21, 1992·Brain Research. Developmental Brain Research·K Unsicker, R Westermann
Oct 1, 1991·American Journal of Respiratory Cell and Molecular Biology·S BuchM Post
Jan 1, 1990·Anatomy and Embryology·A A Ten Have-OpbroekJ A Dubbeldam
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R C Baxter
Jun 1, 1986·Teratology·R E SeegmillerJ C Carey
Dec 1, 1982·The Journal of Pediatrics·P Helms, J Stocks
Dec 1, 1995·Developmental Biology·P MinooR deLemos
Mar 30, 1999·Experimental Cell Research·L F Lau, S C Lam
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·A BenachiT Ryder
May 13, 1999·Proceedings of the Society for Experimental Biology and Medicine·B J Desai, H E Gruber
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·J A GutierrezL G Dobbs
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·B S TsengI J Butler
Oct 29, 2000·Journal of Applied Physiology·M Liu, M Post
Jul 7, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·H ZhouM A Greco
Jan 5, 2002·Industrial & Engineering Chemistry Research·G N Stamatas, L V McIntire
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph A KittermanJon Goerke
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Nadia Abdel-WahabRoger M Mason
Nov 13, 2002·Annual Review of Physiology·Mary C Williams
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Jorge A GutierrezLeland G Dobbs
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paul R ReynoldsJeffrey A Whitsett
Aug 9, 2003·The Journal of Endocrinology·D R Brigstock
Dec 10, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Andrew Leask, David J Abraham
Jan 16, 2004·Lancet·Bernard Perbal
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J K CreanF Martin
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mohammad Reza Inanlou, Boris Kablar
Apr 22, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mohammad Reza Inanlou, Boris Kablar
Sep 6, 2005·American Journal of Respiratory Cell and Molecular Biology·Sheng-Hua WuZi-Qing Chen
Jul 22, 2006·The FEBS Journal·Brahim Chaqour, Margarete Goppelt-Struebe

❮ Previous
Next ❯

Citations

Jan 25, 2011·Pediatric Surgery International·Elke Maria RuttenstockPrem Puri
Dec 2, 2011·Nature Reviews. Drug Discovery·Joon-Il Jun, Lester F Lau
May 23, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liya PiEdward W Scott
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Akihisa MitaniHiroki Kurihara
Jun 23, 2009·American Journal of Respiratory Cell and Molecular Biology·Shu WuEduardo Bancalari
Mar 17, 2009·Respiratory Research·Megan J WallaceStuart B Hooper
Oct 5, 2011·Critical Reviews in Eukaryotic Gene Expression·John A ArnottSteven N Popoff
Feb 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lucas L FalkeTri Quang Nguyen
Feb 20, 2014·BioMed Research International·Po-Chun ChenChih-Hsin Tang
Oct 15, 2014·Nature Reviews. Nephrology·Helena M KokTri Q Nguyen
Aug 23, 2011·Cellular and Molecular Life Sciences : CMLS·Faith Hall-Glenn, Karen M Lyons
Oct 14, 2010·Experimental Lung Research·Carmen Mesas BurgosBjörn Frenckner
Oct 27, 2015·International Journal of Molecular Medicine·Jun LiWen G Jiang
Feb 6, 2013·Vascular Pharmacology·Markella Ponticos
Aug 14, 2012·Cytokine & Growth Factor Reviews·Alyssa Charrier, David R Brigstock
Mar 2, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Irena Rot, Boris Kablar
Jul 28, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mark Baguma-Nibasheka, Boris Kablar
Oct 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alex G LambiSteven N Popoff
Nov 30, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shawn K Ahlfeld, Simon J Conway
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Steffen KunzmannBoris W Kramer
Sep 16, 2008·Trends in Biochemical Sciences·Kenneth P HolbournBernard Perbal
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Jul 19, 2017·Antioxidants & Redox Signaling·David Labrousse-AriasMaría J Calzada
Oct 18, 2018·Experimental Dermatology·Pauline HenrotMuriel Cario
Sep 6, 2019·American Journal of Respiratory Cell and Molecular Biology·Hideaki IsagoTakahide Nagase
Feb 6, 2020·Journal of Cell Communication and Signaling·Lucas L FalkeRoel Goldschmeding
Apr 16, 2020·Journal of Cell Communication and Signaling·Lucas L FalkeRoel Goldschmeding
Apr 28, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Niki NoeGianluca Turcatel
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Zihao ChenBao-Ting Zhang
Jan 12, 2021·Journal of Cell Communication and Signaling·Roos J LeguitRoel Goldschmeding
Jan 9, 2021·Journal of Cell Communication and Signaling·Sukhbir Kaur, David D Roberts
Oct 7, 2021·Journal of Cell Communication and Signaling·Viktor Zaykov, Brahim Chaqour

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