Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.

American Journal of Respiratory Cell and Molecular Biology
Joshua G McCaskillStephen L Tilley

Abstract

Propionibacterium acnes (PA) is a gram-positive anaerobic bacterium implicated as a putative etiologic agent of sarcoidosis. To characterize the pulmonary immune response to PA, C57BL/6 and BALB/c mice were intraperitoneally sensitized and intratracheally challenged with heat-killed bacteria. C57BL/6 mice challenged with PA developed a cellular immune response characterized by elevations in Th1 cytokines/chemokines, increased numbers of lymphocytes and macrophages in lung lavage fluid, and peribronchovascular granulomatous inflammation composed of T- and B-lymphocytes and epithelioid histiocytes. T-lymphocytes in the lung lavage fluid showed a marked CD4+ cell predominance. In contrast, C57BL/6 mice challenged with Staphylococcus epidermidis (SE), another gram-positive commensal of human skin, and BALB/c mice challenged with PA, showed only a modest induction of Th1 cytokines, less pulmonary inflammation, and no granulomatous changes in the lung. Enhancement of Toll-like receptor expression was seen in PA-exposed C57BL/6 mice within 24 h after exposure, suggesting that induction of innate immunity by PA contributes to the robust, polarized Th1 immune response elicited by this bacterium. These findings suggest that PA-induced pu...Continue Reading

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Citations

Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Tsutomu ShinoharaYoshimi Shibata
Mar 30, 2010·American Journal of Respiratory Cell and Molecular Biology·Carmen M SwaisgoodWonder P Drake
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Sep 9, 2016·American Journal of Respiratory Cell and Molecular Biology·Jessica L WernerGabriel Núñez
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Jul 9, 2016·Current Opinion in Pulmonary Medicine·Florence JenyJean-François Bernaudin

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