Pulmonary immunity to Pseudomonas aeruginosa

Immunology and Cell Biology
A W CrippsJ Kyd

Abstract

Pseudomonas aeruginosa, an opportunistic bacterial pathogen, is a major course of morbidity and mortality in subjects with compromised respiratory function despite the significant advances in therapeutic practices. The bacteria produces an armoury of products which modify its infective niche to ensure bacterial survival. The role of antibody in protection against pulmonary infection remains poorly defined. Protection appears to be associated with opsonizing antibody whilst some other antibody responses may be deleterious and promote further lung damage. Cell mediated responses are clearly important in protection against infection. This review proposes a vaccine strategy aimed at enhancing specific T cell responses in the lung which, though T cell-derived cytokines, drive the recruitment of neutrophils to the lung and the subsequent activation of these cells results in the clearance of bacteria from the lung.

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Citations

Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Zhijun SongNiels Høiby
Sep 10, 2013·PloS One·Robert D JunkinsTong-Jun Lin
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Jul 22, 2014·The American Journal of Pathology·Robert D JunkinsTong-Jun Lin
Apr 21, 2005·The Journal of Clinical Investigation·Stefan WorgallRonald G Crystal
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Svetlana O CarriganTong-Jun Lin
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie R PowerTong-Jun Lin
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Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tong-Jun LinAndrew C Issekutz
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