Pulmonary innate immunity in children with protracted bacterial bronchitis

The Journal of Pediatrics
Anne B ChangJohn W Upham

Abstract

To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human β-defensin-2 [hBD2], mannose-binding lectin [MBL], and surfactant protein-A [SP-A]), the relationship with airway neutrophilia and infection, and cytokine production of stimulated BAL cells in children with current protracted bacterial bronchitis (PBB), children with resolved PBB (PBB well), and controls. BAL of 102 children (mean age 2.8 years) fulfilling predefined criteria of current PBB (n = 61), PBB well (n = 20), and controls (n = 21) was cultured (quantitative bacteriology) and viruses examined by polymerase chain reaction. hBD2, MBL, and SP-A were measured, and cytokine production by lipopolysaccharide-stimulated BAL cells was determined. Median hBD2 and MBL levels were significantly higher in the current PBB group (hBD2 = 164.4, IQR 0-435.5 pg/mL; MBL = 1.7, 0.4-4 ng/mL) than in the PBB well group (hBD2 = 0, IQR 0-85.2; MBL = 0.6, IQR 0.03-2.9) and controls (hBD2 = 3.6, IQR 0-126; MBL = 0.4, IQR 0.02-79). hBD2 was significantly higher in children with airway infection (n = 54; median 76.9, IQR 0-397.3) compared with those without (n = 48; 0, IQR 0-236.3), P= .04. SP-A levels and cytokine production of stimulated BAL cells were simil...Continue Reading

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Citations

Sep 7, 2013·Early Human Development·Ahmad KantarOliviero Sacco
Mar 7, 2014·Annals of the American Thoracic Society·Christopher J van der GastLucas R Hoffman
Jun 25, 2014·Paediatric Respiratory Reviews·A B ChangG J Redding
Mar 5, 2015·Expert Opinion on Emerging Drugs·Anne B ChangLucas R Hoffman
Dec 5, 2015·Pediatric Pulmonology·Anne B ChangKeith Grimwood
Feb 4, 2016·Pediatric Pulmonology·Vikas GoyalAnne B Chang
Oct 13, 2015·Lung·Ahmad Kantar
Oct 16, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Danielle F WurzelAnne B Chang
Aug 25, 2015·The Lancet. Respiratory Medicine·Anne B ChangJohn W Upham
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Aug 28, 2015·Pediatric Annals·Aneela BidiwalaSameer J Patel
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Aug 28, 2020·Frontiers in Pediatrics·Marcella GallucciGiampaolo Ricci
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