PMID: 1198086Jan 1, 1975Paper

Pulmonary lesions and autoimmune reactions after long-term nitrofurantoin treatment

Scandinavian Journal of Respiratory Diseases
R LundgrenL G Wiman

Abstract

Hypersensitivity reactions in two women with pulmonary lesions, autoimmune reactions with positive antinuclear factor and liver damage following long-term nitrofurantoin treatment are discussed. One patient had taken nitrofurantoin for more than 1 year and the other for more than 2 when their symptoms appeared. They were in a very poor condition, but recovered when the drug was withdrawn. Lymphocyte transformation test in vitro showed significant blast-transformation, indicating the involvement of immunological mechanisms. Treatment with corticosteroids had not been instituted.

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