PMID: 3383813May 1, 1988Paper

Pulmonary macrophage antimicrobial activity in canine endotoxin shock and lung injury

Experimental Lung Research
R F JacobsD R Tabor

Abstract

Bacterial sepsis and pneumonia are common complications of lung injury and predispose the host to a poor resolution. We studied the functional integrity of pulmonary macrophages derived from minced lung preparations in a canine model of endotoxin-induced shock with acute lung injury. Dogs given 2 mg/kg of Escherichia coli endotoxin 055:B5 developed classic shock symptoms with concomitant acute lung injury; control animals given saline showed no physiological or pathological abnormalities. Compared to previous work with this canine model, the lung injury in this extended time period (6 h) had progressed to include alveolar edema. Six hours after endotoxin infusion, the left lung was lavaged, perfused, and the resulting lung minced for isolation of pulmonary macrophages. The endotoxic-model pulmonary macrophages showed several significant functional differences from controls. Although they elicited greater production of H2O2 (p less than 0.05), both phagocytosis of radiolabeled Staphylococcus aureus and E. coli (p less than 0.05) and bactericidal activity (p less than 0.05) were diminished compared to controls. Compared to alterations previously described in alveolar macrophages, these cells produced less H2O2 and demonstrated ab...Continue Reading

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Citations

Nov 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·G M Kharin, A Z Shakirova
May 1, 1992·Journal of Veterinary Internal Medicine·C W Frevert, A E Warner
May 1, 1995·Journal of Veterinary Internal Medicine·A K JärvinenM Rajamäki
Nov 1, 1993·The American Review of Respiratory Disease·D WalmrathW Seeger
Dec 5, 1998·Experimental Lung Research·C W FrevertJ D Brain
Aug 1, 1992·The Journal of Surgical Research·C CardozoM Lesser
Oct 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T OvesenO Elbrønd

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