Pulmonary manifestations of the pre-engraftment syndrome after umbilical cord blood transplantation

Annals of Hematology
Kyle R BrownbackOmar S Aljitawi

Abstract

Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation (UCBT) characterized by fever and erythematous skin rash prior to neutrophil engraftment. We sought to determine the incidence and characterize the pulmonary manifestations of PES. A retrospective review of patients who underwent UCBT at the University of Kansas Medical Center over a 5-year period was performed. Data collected included patient baseline characteristics, presence of PES, pulmonary findings, treatments, and survival. Forty-four patients underwent UCBT with 22 of those patients developing PES. Full-intensity myeloablative conditioning regimen was found to be a risk factor for development of PES. Of those 22 patients, 13 had resting hypoxemia. The most common radiographic findings included diffuse ground glass opacities with pleural effusions. Fifteen patients with PES received corticosteroids, of which 12 had improvement in fevers and rash. These patients had a trend toward worse mortality than those not receiving corticosteroids. There was a nonsignificant trend toward worse survival in patients with PES and hypoxemia compared to those without hypoxemia. PES is a common complication following cord blood transplantati...Continue Reading

References

May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 4, 2001·Bone Marrow Transplantation·T R Spitzer
Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry
Jun 29, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Edward GorakRichard Childs
Jul 9, 2005·Transplantation·Yukiko KishiUNKNOWN Tokyo Stem Cell Transplant Consortium
Dec 31, 2005·The New England Journal of Medicine·Lorraine B Ware, Michael A Matthay
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Feb 28, 2008·Journal of Korean Medical Science·Young-Ho LeeSeung-Won Lee
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Irene SchmidMichael H Albert
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Haydar FrangoulJennifer Domm
Oct 28, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kevin J PatelJuliet N Barker
Sep 25, 2012·Bone Marrow Transplantation·K T HongH S Ahn
Feb 6, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Meerim ParkUNKNOWN Korean Cord Blood Transplantation Working Party

❮ Previous
Next ❯

Citations

Oct 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gregory A YanikKenneth R Cooke
Jun 4, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lawrence ChangSung Won Choi
Jan 13, 2015·Bone Marrow Transplantation·T R Spitzer
Apr 13, 2020·Clinical Transplantation·Andrew GrantTracey A O'Brien
Oct 11, 2016·Blood Research·Young-Ho Lee, Wee-Jin Rah
Jul 3, 2021·Transplantation and Cellular Therapy·Doris M PonceUNKNOWN American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
Sep 28, 2021·Transplantation and Cellular Therapy·Ann DahlbergUNKNOWN American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
Aug 2, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takaaki KonumaSatoshi Takahashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.