Pulmonary metastases in children and adolescents with papillary thyroid cancer in China: prognostic factors and outcomes from treatment with 131 I

Endocrine
Xin-Yun ZhangQuan-Yong Luo

Abstract

Papillary thyroid carcinoma (PTC) with pulmonary metastases is rare in children and adolescents. Unlike adults, limited data are available on children with this disease. Thus, this study evaluated the therapeutic efficacy and prognostic factors of individuals less than 21 years of age with pulmonary metastases from PTC. Seventy-six children and adolescents with pulmonary metastases from PTC treated with 131I were retrospectively analyzed. Therapeutic efficacy was evaluated by changes in serum thyroglobulin (Tg) and chest computed tomography (CT). Factors predictive of progression-free survival and overall survival were measured by the Kaplan-Meier method. Among the 76 patients included in this study, 22.4% (17 of 76) were less than 15 years old and 65.8% (50 of 76) were female. Under the evaluation of stimulated serum Tg levels, RAI treatment were effective in 55.9% (38 of 68), stable in 26.5% (18 of 68) and ineffectvie in 17.6% (12 of 68) of patients. Changes on anatomical imaging suggested complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) in 8.5, 62.0, 15.5, and 14.1% of individuals, respectively. Univariate analysis showed that size and tumor doubling time of pulmonary metastases...Continue Reading

References

Jul 28, 2009·The Journal of Surgical Research·Anthony R HoganJuan E Sola
Sep 24, 2010·Thyroid : Official Journal of the American Thyroid Association·Melissa PawelczakBina Shah
Jul 29, 2011·The Journal of Clinical Endocrinology and Metabolism·Zhong-Ling QiuQuan-Yong Luo
May 2, 2012·Journal of Pediatric Hematology/oncology·Louis Rapkin, Farzana D Pashankar
Jul 26, 2012·Thyroid : Official Journal of the American Thyroid Association·Iain J NixonIan Ganly
Dec 20, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Aybala Agac AyAbdullah Cetin
Mar 19, 2014·The Journal of Pediatrics·Lucas Bonachi VergaminiCarlos Rodriguez-Galindo
Sep 12, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Chandra Sekhar BalRamya Soundararajan
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 18, 2015·Thyroid : Official Journal of the American Thyroid Association·Theresa H M KeeganPamela L Horn-Ross
Apr 10, 2015·Annals of Surgical Oncology·Jonathan Lerner, Melanie Goldfarb
Jun 17, 2015·Thyroid : Official Journal of the American Thyroid Association·Stephen H LaFranchi
Jun 25, 2015·European Journal of Endocrinology·Hong-Jun SongQuan-Yong Luo
Dec 18, 2015·The Oncologist·Johanna WassermannLaurence Leenhardt
Feb 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Sadana BalachandarCharles A Sklar
Feb 13, 2016·Thyroid : Official Journal of the American Thyroid Association·Mona M SabraR Michael Tuttle
Mar 11, 2016·The Journal of Clinical Endocrinology and Metabolism·Mariëlle S Klein HesselinkThera P Links
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 21, 2017·Anticancer Research·Marco RussoGabriella Pellegriti
Sep 14, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Courtney OlmstedGeeta Lal
Jan 19, 2018·Italian Journal of Pediatrics·Giuseppina ZirilliMalgorzata Wasniewska

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Citations

Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Marloes NiesSteven G Waguespack

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