Pulmonary neuroendocrine tumors and preneoplasic lesions

Annales de pathologie
Isabelle Rouquette Lassalle

Abstract

In the recently published 2015 World Health Organization (WHO) classification of tumors of the lungs, all neuroendocrine tumors of the lungs are presented for the first time in one single chapter. In this classification, high-grade small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) are differentiated from intermediate grade atypical carcinoids (AC) and low-grade typical carcinoids as well as from preinvasive lesion diffuse neuroendocrine hyperplasia DIPNECH. In the 2004 WHO classification, SCLC and carcinoids each had a separate chapter and LCNEC was listed in the chapter on large cell carcinoma of the lungs. The new WHO classification also gives some recommendations for the diagnosis on small biopsies. This review describes morphological, immunohistochemical, and genomic characteristic of these tumors according to the new classification.

References

Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Birgit Guldhammer SkovElisabeth Brambilla
Jan 15, 2009·American Journal of Clinical Pathology·Cesar A MoranMark R Wick
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W D Travis
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
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Jun 4, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Morena FasanoFloriana Morgillo
Jul 15, 2015·Nature·Julie GeorgeRoman K Thomas
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson

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Citations

May 4, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mathilde PrietoLudovic Fournel

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