Pulmonary nocardiosis: a comparative analysis of Nocardia asteroides and non-asteroides species

Tropical Doctor
Assad AminErum Khan

Abstract

Our study compares the risk factors, clinical presentations and outcomes of pulmonary infections caused by Nocardia asteroides and non-asteroides species. We performed a retrospective cohort study comparing pulmonary infections by both species in patients presenting to a tertiary care hospital in Karachi, Pakistan. Forty-one patients were identified with pulmonary nocardiosis, with 58.5% belonging to the N. asteroids complex. The most common clinical findings were fever and a cough for both groups, with lobar infiltrates being the most common finding on chest radiographs. In vitro testing showed a sensitivity of all species to trimethoprim-sulfamethoxazole (TMP-SMZ), aminoglycosides, ceftriaxone and imipenem. The majority of the patients were treated with TMP-SMZ in combination with other drugs. The results of our study suggest that there is no significant difference in the risk factors, presentations and outcomes of pulmonary infections by N. asteroides and non-asteroides species. Immunocompromised patients are more likely to have unfavorable outcomes.

References

Sep 1, 1976·The Journal of Infectious Diseases·B L BeamanW Causey
Apr 1, 1994·Clinical Microbiology Reviews·B L Beaman, L Beaman
Jul 21, 2001·Respiration; International Review of Thoracic Diseases·B MariC Domingo
Mar 30, 2002·Journal of Clinical Microbiology·Deanna L KiskaDavid J Pettit
Oct 17, 2002·European Journal of Epidemiology·C FarinaA Goglio
Oct 9, 2003·Journal of Clinical Microbiology·Michael A Saubolle, Den Sussland
Apr 21, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Piroon MootsikapunWaraporn Liawnoraset
May 11, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O YildizM Doganay
Apr 15, 2006·Clinical Microbiology Reviews·Barbara A Brown-ElliottRichard J Wallace

❮ Previous
Next ❯

Citations

Dec 13, 2016·Open Forum Infectious Diseases·Sarah L McGuinnessSteven Y C Tong

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Related Papers

International Journal of Emergency Medicine
Muhammad Junaid PatelMuhammad Omer Jamil
Respiration; International Review of Thoracic Diseases
Marialuisa BocchinoCesare Saltini
Scandinavian Journal of Infectious Diseases
E AlpM Doganay
© 2022 Meta ULC. All rights reserved