Pulmonary Nocardiosis due to Nocardia asiatica in a Patient with ANCA-associated Vasculitis

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Koichiro SuemoriMasaki Yasukawa

Abstract

Nocardia asiatica is a rare causative organism responsible for opportunistic infection, and was first reported by Kageyama et al. in 2004. We report herein on a very rare case of N. asiatica infection in a 76-year old male patient with ANCA-associated vasculitis and a history of pulmonary tuberculosis. The patient developed pulmonary nocardiosis due to N. asiatica while receiving glucocorticoid therapy. Chest computed tomography demonstrated multiple granules and cavity formation mainly in the left lower lobe. From the images, we suspected opportunistic infection, possibly pulmonary tuberculosis or pulmonary damage due to ANCA-associated vasculitis. Nocardia sp. was detected from a bronchoalveolar lavage culture and N. asiatica was identified by 16S ribosomal DNA gene sequencing. Cranial magnetic resonance imaging revealed no abnormality. Administration of Doripenem (1.5g/day) and sulfamethoxazole-trimethoprim (4g/day) was started, and the patient's clinical and imaging findings promptly improved. Thereafter, he received sulfamethoxazole-trimethoprim (2g/day) and prednisolone (10 mg/day) as maintenance therapy for ANCA-associated vasculitis for more than one year, and there has since been no recurrence of the Nocardia infection.

References

Mar 1, 1982·Reviews of Infectious Diseases·R J WallaceD C Hollowell
Feb 1, 1997·Seminars in Arthritis and Rheumatism·C C MokC S Lau
Jan 27, 2004·International Journal of Systematic and Evolutionary Microbiology·Akiko KageyamaKazuko Nishimura
May 10, 2006·Clinical Rheumatology·Maria JustinianoLuis R Espinoza
Apr 21, 2007·Journal of Clinical Microbiology·Elisabetta IonaLanfranco Fattorini
Sep 7, 2007·Rheumatology·C LapraikUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Apr 24, 2009·Current Opinion in Ophthalmology·Prajna Lalitha
Jul 14, 2009·Medicine·Maricela Valerio MineroPatricia Muñoz
Feb 11, 2011·General Thoracic and Cardiovascular Surgery·Takako MatsumotoTakamasa Onuki
Nov 29, 2012·Clinical and Experimental Nephrology·Sakae HommaKeita Sato
May 3, 2013·Journal of Clinical Microbiology·Eva LeitnerRobert Krause

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Citations

Apr 23, 2020·Journal of Family Medicine and Primary Care·Sonakshi SrivastavaPallab Ray

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