Pulmonary nocardiosis in fine-needle aspiration cytology smears: Report of four cases

Diagnostic Cytopathology
Sudha SharmaPranab Dey

Abstract

Nocardia has been recognized as a significant opportunistic pathogen in organ transplant patients; however, it is an uncommon pathogen in immunocompetent patients. It may mimic other infectious diseases both clinically and radiologically. We report four cases of pulmonary nocardiosis in three immunocompromised and one immunocompetent patients on fine-needle aspiration cytology (FNAC). Two patients presented with lung consolidation while two had cavitatory lesions. FNAC smears showed inflammatory cells composed of polymorphs and histiocytes along with necrosis. Occasional epithelioid cell granuloma was seen in one case. Modified Ziehl-Neelsen (ZN) stain was performed which highlighted long slender filamentous branching organisms conforming to the morphology of Nocardia. Thus, a suspicion for nocardiosis should be kept while assessing cytologic material especially in immunocompromised individuals. The diagnosis can be confirmed by special stains and culture studies; however, a high index of clinical suspicion is required so that appropriate culture media can be used for high diagnostic yield. FNAC is of help in providing immediate and accurate diagnosis of nocardiosis, thus helping in appropriate medical management.

References

Sep 1, 1976·The Journal of Infectious Diseases·B L BeamanW Causey
Feb 1, 1995·Diagnostic Cytopathology·I BusmanisA Hellyar
Dec 13, 2005·Acta Cytologica·Sandeep MathurKusum Verma
Apr 25, 2007·Mycopathologia·M R ShivaprakashArunaloke Chakrabarti
Jun 2, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Raquel Martínez TomásMiguel Gobernado Serrano
Apr 4, 2012·Mayo Clinic Proceedings·John W Wilson
Oct 23, 2015·Case Reports in Pulmonology·Inderjit SinghDana Zappetti

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Citations

Sep 10, 2017·Diagnostic Cytopathology·Kelsey E McHughDaniel D Rhoads
Jun 8, 2019·Diagnostic Cytopathology·Vijayalakshmi GudivadaNeelaiah Siddaraju
Dec 21, 2021·Diagnostic Cytopathology·Bianca B ChristensenVanda F Torous

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