Pulmonary oedema in rats given dehydromonocrotaline: a topographic and electron-microscope study

The Journal of Pathology
J V Hurley, M V Jago

Abstract

Study of cleared, histological and electron-microscope specimens shows that increased vascular permeability plays a major role in the formation of the pulmonary oedema and pleural effusions that occur in rats following the intravenous injection of a large dose of dehydromonocrotaline. There is a latent interval of 6-8 hr between injection of the dehydroalkaloid and the start of increased permeability which appears to be due to a direct damaging effect of the toxin on the endothelium of pulmonary capillaries and small venules. The endothelial injury does not cause permanent disruption of small blood vessels, and 2 days after injury all vessels are patent and lined by a complete layer of endothelium. Large numbers of mononuclear cells are present in the interstitial tissues of the lung 44 hr after injury. These cells appear to be emigrated blood monocytes but the cause of their emigration and their role in the subsequent progression of this type of injury to the lung are not clear.

References

Apr 1, 1972·The Journal of Pathology·R Plestina, H B Stoner
Feb 24, 1968·Nature·A R Mattocks
Jan 1, 1968·The Journal of Pathology and Bacteriology·K N Ham, J V Hurley

❮ Previous
Next ❯

Citations

Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·W M LafranconiR J Huxtable
Jan 1, 1990·Pharmacology & Therapeutics·R J Huxtable
Mar 29, 2003·Toxicology and Applied Pharmacology·Mei-Jung Chen, Yih-Loong Lai
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Nov 1, 1987·The British Journal of Radiology·E A Vanker
Nov 1, 1987·The British Journal of Radiology·J R PulpeiroE Garcia-Hidalgo
Jan 1, 1985·Experimental Lung Research·K S Hilliker, R A Roth
Nov 1, 1983·Experimental Lung Research·T SugitaJ T Reeves
Dec 1, 1988·Toxicology and Applied Pharmacology·S M White, R A Roth
Jun 1, 1991·Toxicology and Applied Pharmacology·A E SchultzeR A Roth
Jan 1, 1982·Annals of the New York Academy of Sciences·J V Hurley
Aug 1, 1996·Japanese Circulation Journal·S TatebeS Eguchi
Jun 1, 1978·The Journal of Pathology·J V Hurley
Feb 1, 1979·The Journal of Pathology·S L Wood, J V Hurley
Jan 1, 1977·The Journal of Pathology·R PlestinaA R Mattocks
Oct 6, 2018·Veterinary Ophthalmology·Radka AndrysikovaBernhard Spiess
Mar 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·B LiumE Amundsen
Oct 4, 2000·Physiological Reviews·V Hampl, J Herget

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.