PMID: 7036798Mar 1, 1982Paper

Pulmonary oxygen exchange during endobronchial anesthesia: effect of tidal volume and PEEP

Anesthesiology
J A KatzA N Thomas

Abstract

To determine the effects of tidal volume (VT) and positive end-expiratory pressure (PEEP) on pulmonary oxygen exchange during endobronchial (one-lung) anesthesia, the authors studied the effects of VT at 8 and 16 per cent total lung capacity (TLC), at zero end-expiratory pressure (ZEEP), and at 10 cmH2O PEEP in 16 patients in the lateral position. Anesthesia was maintained with halothane and oxygen. During two-lung ventilation (FIO2 0.99), mean PaO2 and physiologic shunt (Qs/Qt) were 421 +/- 12 mmHg and 0.22 +/- 0.02, respectively. During one-lung ventilation, PaO2 decreased and venous admixture (or Qs/Qt) increased in every patient. The magnitude of this decrease correlated directly with preoperative forced expiratory volume in one second (FEV1) (r = 0.66, P less than 0.005). A VT of 16 per cent of TLC at ZEEP resulted in the highest mean PaO2 (210 +/- 30 mmHg) and lowest Qs/Qt (0.35 +/- 0.02), probably as a result of end-inspiratory alveolar recruitment with the least pulmonary blood flow redistribution. When 10 cmH2O PEEP was applied during 16 per cent TLC ventilation, mean PaO2 decreased from 210 +/- 35 to 162 +/- 25 mmHg (P less than 0.05). PEEP did not significantly affect PaO2 during 8 per cent TLC ventilation. At both l...Continue Reading

Citations

Dec 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P SlingerW Triolet
Dec 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujitaK Sekioka
Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T ShimizuI Yoshiya
Sep 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y Nomoto
Jun 4, 2005·Der Anaesthesist·J MotschJ Roggenbach
Sep 27, 2001·Anesthesiology Clinics of North America·P D Slinger, M R Johnston
Sep 27, 2001·Anesthesiology Clinics of North America·L L Szegedi
Sep 27, 2001·Anesthesiology Clinics of North America·E Cohen
Nov 7, 1998·Journal of Clinical Anesthesia·C D BoucekN G Bircher
May 4, 2000·Journal of Cardiothoracic and Vascular Anesthesia·P D Slinger, M R Johnston
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·B E Marshall
Jan 1, 1996·Acta Anaesthesiologica Scandinavica·G Hedenstierna, A Reber
Jul 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yeung-Leung ChengChing Tzao
May 1, 1993·Veterinary Surgery : VS·J E QuandtM R Raffe
Oct 1, 1995·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K IlkhanipourJ J Menegazzi
Jan 1, 2011·ZooKeys·Vytautas TamutisRomas Ferenca
Nov 13, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Charles L BrassardJean S Bussières
Mar 21, 2006·Current Opinion in Anaesthesiology·Mert Sentürk
Jan 16, 2008·Current Opinion in Anaesthesiology·Andrew Ian LevinAndre Coetzee
Jun 1, 1996·Anesthesiology·G B HammerJ B Brodsky
Jun 23, 2007·Anesthesiology·Mert Sentürk
May 1, 1997·European Journal of Anaesthesiology·Y DikmenH Erolçay
Oct 8, 2013·Journal of Clinical Anesthesia·Naveed SiddiquiZeev Friedman
Oct 24, 2012·Anesthesiology Clinics·Marcos F Vidal MeloDavid W Kaczka
Jul 14, 2004·Chest·Robert James CerfolioAlfred A Bartolucci
Jul 9, 2010·Best Practice & Research. Clinical Anaesthesiology·Beatrice Beck-Schimmer, Ralph C Schimmer
May 6, 2008·Anesthesiology Clinics·Jens Lohser
Dec 18, 2007·Journal of Clinical Anesthesia·Michael T GanterChristoph K Hofer
Dec 9, 2015·Best Practice & Research. Clinical Anaesthesiology·Mert ŞentürkEdmond Cohen
Sep 5, 2008·Paediatric Anaesthesia·Mary C TherouxThomas L Miller
May 16, 1998·Journal of Cardiothoracic and Vascular Anesthesia·P D Slinger, D R Hickey
Jan 1, 1985·Acta Anaesthesiologica Scandinavica·M DarowskiS Baehrendtz
Aug 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·E Cohen, J B Eisenkraft
Jan 1, 1982·Annales Françaises D'anesthèsie Et De Rèanimation·C GranthilC Colavolpe
Feb 15, 2005·Thoracic Surgery Clinics·Peter D Slinger, Michael R Johnston

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