Pulmonary phospholipids in amniotic fluid of pathologic pregnancies: relationship with clinical status of the newborn

Scandinavian Journal of Clinical and Laboratory Investigation
A ZapataJ A Usandizaga

Abstract

We evaluated phospholipids, C-peptide and cortisol levels in amniotic fluid of 203 pathologic pregnancies (63, class A, B and C diabetics; 11 class D, F and H diabetics; 44 preclampsia and 85 Rh-isoimmunization); the control group was 82 normal pregnant women. There was an acceleration of fetal pulmonary maturation in women with preclampsia and severe Rh-isoimmunization in class D, F and H diabetics (at 34 weeks gestation the incidence of mature surfactant (lecithin/sphingomyelin greater than or equal to 2.7 and presence of phosphatidyl-glycerol) in these groups was 30%, 50% and 100%, respectively, while it was zero in the control group). At 37 and 38 weeks only 44.4% of the class A, B and C diabetics had mature surfactant and there was a significant difference with respect to the control group (x2 = 4.9; p less than 0.05); C-peptide levels in these diabetics (class A, B and C) were higher than in controls (p less than 0.001); in pregnant women with accelerated fetal lung maturation they were lower. We demonstrated a close relationship between fetal pulmonary maturity and the type of surfactant in amniotic fluid, which was independent of gestational age.

References

Apr 15, 1979·American Journal of Obstetrics and Gynecology·R BustosE Lowenberg
Feb 15, 1977·American Journal of Obstetrics and Gynecology·J C MorrisonS A Fish
Feb 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·A ZapataP de la Fuente
Feb 27, 1980·Biochemical and Biophysical Research Communications·M Hallman, B L Epstein
Mar 15, 1984·American Journal of Obstetrics and Gynecology·R W QuinlanA C Cruz
Sep 1, 1982·British Journal of Obstetrics and Gynaecology·M J WhittleR W Logan

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Citations

Mar 24, 1999·Early Human Development·Y G GollinG Papandonatos

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