Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Kyoichi KairaNobuyuki Yamamoto

Abstract

Pulmonary pleomorphic carcinoma is a rare epithelial tumor and has an aggressive clinical course. As few studies of pulmonary pleomorphic carcinoma have been described, the clinicopathological characteristics of the disease remain unclear. Especially, the information on the epidermal growth factor receptor (EGFR) mutation status of pulmonary pleomorphic carcinoma is sparse. We retrospectively examined 17 patients with pulmonary pleomorphic carcinoma. EGFR mutation and Ki-67 labeling index were investigated in these patients. The median age of the patients was 72 years (range, 47-84 years). Thirteen patients were men and four were women. EGFR mutation was observed in 3 (18%) of 17 patients. The median value of Ki-67 labeling index was 62% (range, 20-87%). Positron emission tomography with 18-fluorodeoxy-glucose was performed in 16 patients, and the standardized uptake value tended to be high (median 19.3). The survival of patients without surgery demonstrated a significantly poor prognosis compared with those with surgery (P = 0.0096). Palliative chemotherapy was almost poor response in advanced pulmonary pleomorphic carcinoma. The response to gefitinib in a patient with EGFR mutation was small and transient. EGFR mutation was r...Continue Reading

References

Sep 15, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Y L ChangC T Wu
Jun 19, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hyun-Mi BaeDae Seog Heo
Oct 19, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Satoshi YamamotoTakayuki Shirakusa
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kyoichi KairaMasatomo Mori
Feb 29, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masahiro EndoToru Kameya
Sep 20, 2008·Virchows Archiv : an International Journal of Pathology·J H J M van KriekenA Ensari
Jul 7, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenichiro ItoUNKNOWN Hokkaido Lung Cancer Clinical Study Group
Dec 1, 2000·European Journal of Nuclear Medicine·K HigashiI Yamamoto

❮ Previous
Next ❯

Citations

Jun 1, 2011·Journal of Cancer Research and Clinical Oncology·Soohyeon LeeMyung-Ju Ahn
May 11, 2011·International Journal of Clinical Oncology·Miyako SaitohKoichiro Tatsumi
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A F Gazdar
Jan 10, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fengshi ChenHiroshi Date
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Kai ZhangPhilip T Cagle
Oct 4, 2013·World Journal of Surgical Oncology·Si-Yuan HuangXing-Ya Li
Jan 26, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giuseppe PelosiGabriella Sozzi
Apr 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasushi MurakamiMasahide Oki
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Jan 7, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thibault VieiraMarie Wislez
Aug 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Teruo IwasakiKunimitsu Kawahara
Nov 17, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E Giroux LeprieurM Wislez
Feb 5, 2014·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hidefumi KohShigemichi Hirose
Mar 11, 2016·Expert Review of Respiratory Medicine·Elaine ShumBalazs Halmos
Apr 24, 2016·Clinical Lung Cancer·Mony UngJulien Mazières
May 15, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V FalletM Wislez
Jun 19, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giuseppe PelosiMauro Papotti
Apr 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yih-Leong ChangPan-Chyr Yang
May 10, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Filippo LococoAlessia Ciarrocchi
Aug 16, 2016·Surgical Pathology Clinics·Lynette M Sholl
Jul 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xuewen LiuAlain C Borczuk
Mar 21, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexa B SchrockJane J Liu
Mar 9, 2018·Case Reports in Oncology·Daisuke NakamuraKen-Ichi Ito
Sep 15, 2020·Therapeutic Advances in Medical Oncology·Xin LiJun Chen
May 9, 2019·International Journal of Clinical Oncology·Xiaohong LiangChong Li
Nov 1, 2020·BMJ Case Reports·Hirotaka SaikawaMakoto Maemondo
Jun 24, 2021·NPJ Precision Oncology·Masaaki NaganoHiroyuki Mano
Aug 16, 2021·International Journal of Surgery Case Reports·Francesco TormenBeatrice Aramini
Apr 28, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takaaki MizunoYuichiro Ohe
Sep 1, 2013·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Keith M Kerr, Marianne C Nicolson
Jun 22, 2018·Case Reports in Oncology·Eriko FujimotoTakashi Kijima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

© 2021 Meta ULC. All rights reserved