Pulmonary-renal crosstalk in the critically ill patient

Revista chilena de pediatría
Alejandro Donoso FPablo Cruces R

Abstract

Despite advances in the development of renal replacement therapy, mortality of acute renal failure remains high, especially when occurring simultaneously with distant organic failure as it is in the case of the acute respiratory distress syndrome. In this update, birideccional deleterious relationship between lung and kidney on the setting of organ dysfunction is reviewed, which presents important clinical aspects of knowing. Specifically, the renal effects of acute respiratory distress syndrome and the use of positive-pressure mechanical ventilation are discussed, being ventilator induced lung injury one of the most common models for studying the lung-kidney crosstalk. The role of renal failure induced by mechanical ventilation (ventilator-induced kidney injury) in the pathogenesis of acute renal failure is emphasized. We also analyze the impact of the acute renal failure in the lung, recognizing an increase in pulmonary vascular permeability, inflammation, and alteration of sodium and water channels in the alveolar epithelial. This conceptual model can be the basis for the development of new therapeutic strategies to use in patients with multiple organ dysfunction syndrome.

References

Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·J E Fewell, G C Bond
Jan 1, 1991·Journal of Applied Physiology·P AndrivetC Brun-Buisson
Apr 1, 1971·Archives of Internal Medicine·K H Kilburn, A R Dowell
Sep 1, 1984·The Journal of Surgical Research·R J MullinsS M Banks
Jul 24, 1995·Archives of Internal Medicine·G M ChertowJ M Lazarus
Jan 1, 1995·Biology of the Neonate·D S SemamaJ P Guignard
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·Y KohdaR A Star
Aug 15, 1998·The American Journal of the Medical Sciences·A L Weigert, A I Schafer
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jun 29, 2000·JAMA : the Journal of the American Medical Association·V M RanieriA S Slutsky
Jun 5, 2001·Pediatrics·S L GoldsteinR Sachdeva
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Neesh Pannu, Ravindra L Mehta
Nov 21, 2002·Critical Care Medicine·Elisa EstenssoroJavier Osatnik
Nov 28, 2002·Current Opinion in Critical Care·Ravindra L MehtaMiet Schetz
Mar 13, 2003·Kidney International·Hamid RabbManoocher Soleimani
Mar 29, 2003·American Journal of Respiratory and Critical Care Medicine·Won-Il ChoiCharles A Hales
May 23, 2003·Journal of the American Society of Nephrology : JASN·K J Kelly
Jan 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jiangping DengRobert A Star
Nov 4, 1950·Journal of the American Medical Association·H E BASS, E SINGER
Oct 2, 2004·Kidney International·Ravindra L MehtaUNKNOWN Program to Improve Care in Acute Renal Disease
Nov 2, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert S GillespieJordan M Symons
Jun 9, 2005·Critical Care Medicine·Jan Willem KuiperFrans B Plötz
Aug 16, 2005·Chest·Renee D StapletonKenneth P Steinberg
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawTom Rosenal
Sep 1, 1947·The Journal of Clinical Investigation·D R DruryJ Goodman
Sep 2, 2006·Experimental Biology and Medicine·Ramón RodrigoCleofina Bosco
Jan 26, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Dennis BaileyFrance Gauvin
Feb 27, 2007·Nature Clinical Practice. Nephrology·Stephanie J HedgesAnthony J Busti
Mar 1, 2007·American Journal of Physiology. Renal Physiology·Heitham T HassounHamid Rabb
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Dec 7, 2007·Kidney International·W K HanJ V Bonventre
Dec 13, 2007·Critical Care Medicine·Kathleen D LiuUNKNOWN National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group

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