Pulmonary resection for nontuberculous mycobacterial pulmonary disease: outcomes and risk factors for recurrence

General Thoracic and Cardiovascular Surgery
Takuma YotsumotoHirotoshi Matsui

Abstract

As the number of patients with nontuberculous mycobacterial pulmonary disease (NTMPD) increases, surgical treatment to control disease becomes more important. However, postoperative outcomes and predictors of recurrence have been insufficiently evaluated. We retrospectively investigated 100 patients with NTMPD who underwent pulmonary resection from 2009 to 2016 at our institution. Clinical data of patients with and without postoperative recurrence were statistically compared. Recurrence was defined as microbiological re-identification or computed tomography findings highly suspicious for relapse after excluding other diseases. Recurrence-free survival was calculated using the Kaplan-Meier method. Survival curves were compared using the log-rank test. Predictive factors were evaluated using univariate and multivariate analyses. Nine patients experienced recurrence. A significant difference in recurrence-free survival was detected between patients with and without a positive preoperative sputum culture (P = 0.000942). Moreover, patients with a positive preoperative sputum smear (≥ 2 +) had a significantly higher recurrence rate than those who did not (P = 0.000216). Multivariate analysis revealed that preoperative sputum smear (≥...Continue Reading

References

Aug 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A WeberW Weder
Jun 5, 2004·The European Respiratory Journal·M T HenryJ P Watson
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Kwok C ChangCheuk M Tam
Aug 16, 2006·American Journal of Respiratory and Critical Care Medicine·Kwok C ChangCheuk M Tam
Dec 2, 2006·The European Respiratory Journal·M DaillouxUNKNOWN French Mycobacteria Study Group
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Oct 12, 2007·Journal of Clinical Microbiology·Moises PalaciKathleen D Eisenach
Jun 28, 2008·Journal of Korean Medical Science·Won-Jung KohJhingook Kim
Oct 28, 2009·Chest·Rhonda E ColomboKenneth N Olivier
Dec 21, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lei YuTianxiang Gu
Dec 22, 2010·The Annals of Thoracic Surgery·Peng ZhangWen Gao
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julie JarandCharles L Daley
Feb 9, 2012·American Journal of Respiratory and Critical Care Medicine·Jennifer AdjemianD Rebecca Prevots
Mar 6, 2012·The Annals of Thoracic Surgery·John D MitchellMarvin Pomerantz
Apr 27, 2013·The Annals of Thoracic Surgery·Yuji ShiraishiKiyomi Shimoda
Mar 11, 2015·Antimicrobial Agents and Chemotherapy·Bo Young LeeKyung-Wook Jo
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takanori AsakuraMotofumi Ouchi
Apr 3, 2018·Journal of Thoracic Disease·Tadashi SakaneYoshihiro Miyamoto
Nov 6, 2018·General Thoracic and Cardiovascular Surgery·Katsuo YamadaKenji Ogawa

❮ Previous
Next ❯

Citations

Oct 8, 2021·BMC Pulmonary Medicine·Joong-Yub KimNakwon Kwak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.